V-ATPase G3 Activators
V-ATPase G3 Activators, such as Forskolin, IBMX, and 8-Br-cAMP, function through the activation of adenylate cyclase, which increases the levels of intracellular cAMP. These increased cAMP levels in turn activate Protein Kinase A (PKA), which phosphorylates and activates ATP6V1G3, enhancing V-ATPase activity. Some activators, including Bafilomycin A1 and Concanamycin A, function by inhibiting V-ATPase, which leads to an accumulation of protons in the cytosol. This triggers a compensatory response that includes the activation of ATP6V1G3.
Another group of activators, such as LY294002 and Rottlerin, act through the inhibition of other pathways, which leads to an upregulation of PKA activity and subsequent phosphorylation and activation of ATP6V1G3. In contrast, Okadaic acid and Calyculin A function by inhibiting protein phosphatases, such as PP1 and PP2A, which prevents the dephosphorylation of ATP6V1G3, maintaining its active state. Lastly, activators such as FTY720 and Zardaverine function by increasing cAMP levels through different mechanisms, leading to the activation of PKA and subsequent phosphorylation and activation of ATP6V1G3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing intracellular cAMP levels. The increased cAMP levels activate protein kinase A (PKA), which phosphorylates and activates ATP6V1G3, enhancing V-ATPase activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific phosphodiesterase inhibitor, leading to increased cAMP levels. Elevated cAMP activates PKA, which phosphorylates and activates ATP6V1G3. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Br-cAMP is a cell-permeable cAMP analog. By directly increasing cAMP levels, it activates PKA, leading to the phosphorylation and activation of ATP6V1G3. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 inhibits V-ATPase reversibly. This results in an accumulation of protons in the cytosol, which can stimulate a compensatory response leading to the activation of ATP6V1G3. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $66.00 $167.00 $673.00 $2601.00 | 109 | |
Like Bafilomycin A1, Concanamycin A inhibits V-ATPase, leading to increased cytosolic proton concentration. This can trigger a compensatory response, activating ATP6V1G3. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits PI3K, leading to decreased Akt activity. This can lead to an upregulation of PKA activity, which phosphorylates and activates ATP6V1G3. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A). By preventing dephosphorylation, it maintains the phosphorylated (active) state of ATP6V1G3. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases, such as PP1 and PP2A. By inhibiting these phosphatases, it maintains the phosphorylated, active state of ATP6V1G3. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
FTY720 is a sphingosine 1-phosphate receptor modulator. Its action leads to the activation of adenylate cyclase, increasing cAMP levels, and subsequently activating ATP6V1G3 via PKA. | ||||||
Rottlerin | 82-08-6 | sc-3550 sc-3550B sc-3550A sc-3550C sc-3550D sc-3550E | 10 mg 25 mg 50 mg 1 g 5 g 20 g | $84.00 $166.00 $302.00 $2091.00 $5212.00 $16657.00 | 51 | |
Rottlerin is a PKC delta inhibitor. Its action can shift the cellular balance towards PKA activity, leading to increased phosphorylation and activation of ATP6V1G3. | ||||||