V-ATPase A1 Activators
V-ATPase A1 activators belong to a specific chemical class of compounds that interact with and modulate the activity of the Vacuolar-type ATPase (V-ATPase) A1 subunit. V-ATPases are essential proton pumps found in the membranes of various cellular organelles, including lysosomes, endosomes, and the Golgi apparatus. They play a crucial role in regulating intracellular pH, membrane trafficking, and cellular homeostasis. V-ATPase A1 activators specifically target the A1 isoform of the V-ATPase catalytic subunit, which is predominantly expressed in certain tissues and cell types.
These activators function by binding to the A1 subunit of V-ATPase and promoting its enzymatic activity. The V-ATPase complex consists of multiple subunits, including catalytic (A) and regulatory (B) subunits. The A1 subunit is a key component responsible for ATP hydrolysis and proton transport. Activators of V-ATPase A1 enhance the pump's ability to hydrolyze ATP and pump protons across membranes. This modulation of V-ATPase activity can have profound effects on cellular processes, such as the acidification of organelles, vesicle trafficking, and ion homeostasis. Consequently, V-ATPase A1 activators are valuable tools in cell biology research, helping scientists to dissect and better understand the intricacies of intracellular pH regulation and membrane dynamics. By elucidating these processes, researchers can gain insights into various physiological and pathological phenomena.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing cAMP levels, which can lead to the activation of protein kinase A (PKA) and subsequently enhance the expression of V-ATPase A1. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diacylglycerol analogue that activates protein kinase C (PKC), potentially leading to the increased expression of V-ATPase A1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid regulates gene expression through its receptors, which could include genes related to V-ATPase A1, influencing its expression levels. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
As a glucocorticoid, dexamethasone can regulate the expression of various genes, potentially including V-ATPase A1, through its interaction with glucocorticoid receptors. | ||||||
L-3,3′,5-Triiodothyronine, Sodium Salt | 55-06-1 | sc-205725 | 250 mg | $115.00 | ||
T3, the active form of thyroid hormone, can modulate the expression of numerous genes, possibly including V-ATPase A1, via thyroid hormone receptors. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 can be converted to its active form, calcitriol, which binds to the vitamin D receptor (VDR) and influences the expression of target genes, potentially including V-ATPase A1. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin signaling can lead to the activation of various pathways that may enhance the expression of proteins, including V-ATPase A1, required for cellular function. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estrogen binds to its receptors and modulates the expression of target genes, which could include genes related to V-ATPase A1. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
cAMP is a second messenger that can activate PKA, leading to changes in gene expression and potentially upregulating V-ATPase A1. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can activate various signaling pathways, including sirtuins, which might influence the expression levels of V-ATPase A1. | ||||||