Date published: 2025-10-30

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L-3,3′,5-Triiodothyronine, Sodium Salt (CAS 55-06-1)

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Alternate Names:
T3, Na; Triostat; Cytomel; Tertroxin
Application:
L-3,3′,5-Triiodothyronine, Sodium Salt is a compound that stimulates respiratory activity at the mitochondrial level
CAS Number:
55-06-1
Purity:
≥99%
Molecular Weight:
672.96
Molecular Formula:
C15H11I3NNaO4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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L-3,3′,5-Triiodothyronine, sodium salt, known as T3 in its salt form, is extensively used in research focused on thyroid hormone action and metabolism. As an active form of thyroid hormone, it is pivotal for studies investigating the regulation of metabolic rate, development, and differentiation within cells. Scientists leverage L-3,3′,5-Triiodothyronine, sodium salt to explore its influence on gene expression, particularly genes that are responsive to thyroid hormone levels in the body. In vitro, this compound facilitates the investigation of thyroid hormone receptors and the biochemical pathways they regulate, which has implications for understanding metabolic disorders and certain cardiovascular diseases. Additionally, T3 sodium salt is utilized in research concerning developmental biology, as thyroid hormones are vital for normal growth and maturation in vertebrates.


L-3,3′,5-Triiodothyronine, Sodium Salt (CAS 55-06-1) References

  1. Inhibition of cyclin E-cyclin-dependent kinase 2 complex formation and activity is associated with cell cycle arrest and withdrawal in oligodendrocyte progenitor cells.  |  Ghiani, C. and Gallo, V. 2001. J Neurosci. 21: 1274-82. PMID: 11160398
  2. Expression of the green fluorescent protein in the oligodendrocyte lineage: a transgenic mouse for developmental and physiological studies.  |  Yuan, X., et al. 2002. J Neurosci Res. 70: 529-45. PMID: 12404507
  3. c-Myc-dependent transcriptional regulation of cell cycle and nucleosomal histones during oligodendrocyte differentiation.  |  Magri, L., et al. 2014. Neuroscience. 276: 72-86. PMID: 24502923
  4. Chromatin landscape defined by repressive histone methylation during oligodendrocyte differentiation.  |  Liu, J., et al. 2015. J Neurosci. 35: 352-65. PMID: 25568127
  5. Interactions of thyroid hormone and tricyclic antidepressants on rat brain beta-adrenoceptor function.  |  Catto, LC., et al. 1987. Arch Toxicol Suppl. 11: 247-9. PMID: 2820355
  6. Contribution of non-ADH pathways to ethanol oxidation in hepatocytes from fed and hyperthyroid rats. Effect of fructose and xylitol.  |  Vind, C. and Grunnet, N. 1985. Biochem Pharmacol. 34: 655-61. PMID: 3156600
  7. Influence of thyroid hormones on the number of nucleoli and the degree of polyploidy in rat liver.  |  Schlatterer, B. and Paul, HS. 1974. Acta Anat (Basel). 90: 563-72. PMID: 4460678
  8. Effect of thyroid hormones on the activities of hepatic alcohol metabolizing enzymes.  |  Moreno, F., et al. 1979. Biochem Biophys Res Commun. 89: 806-12. PMID: 486198
  9. Variations in the glycosylation of the collagen synthesized by chick embryo cartilage. Effects of development and several hormones.  |  Blumenkrantz, N. and Prockop, DJ. 1970. Biochim Biophys Acta. 208: 461-6. PMID: 5506576
  10. Hepatic microsomal ethanol-oxidizing system (MEOS): increased activity following propylthiouracil administration.  |  Moreno, F., et al. 1981. Alcohol Clin Exp Res. 5: 85-91. PMID: 7013553
  11. Alterations of hepatic alcohol metabolizing enzyme activities due to thyroid hormones.  |  Moreno, F., et al. 1980. Adv Exp Med Biol. 132: 109-15. PMID: 7424701
  12. Developmental and hormonal regulation of the Xenopus liver-type arginase gene.  |  Xu, Q., et al. 1993. Eur J Biochem. 211: 891-8. PMID: 7916684
  13. Effect of 3,3'-di-iodothyronine and 3,5-di-iodothyronine on rat liver mitochondria.  |  Lanni, A., et al. 1993. J Endocrinol. 136: 59-64. PMID: 8381457
  14. Regulation of beta myosin heavy chain, c-myc and c-fos proto-oncogenes in thyroid hormone-induced hypertrophy of the rat myocardium.  |  Green, NK., et al. 1993. Clin Sci (Lond). 84: 61-7. PMID: 8382136

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

L-3,3′,5-Triiodothyronine, Sodium Salt, 250 mg

sc-205725
250 mg
$113.00

Your website states solubility in 1 M HCl:EtOH (1:4) (10 mg/mL). I have dissolved the powder in 1 M HCl:EtOH with a ratio of 1:4, based on the instructions. I would like to know that how long does it be stable in the HCl:EtOH solution at -20 °C? Do you h

Asked by: Aror
Thank you for your question. Please contact your local distributor or technical service for further assistance.
Answered by: Tech Service 1
Date published: 2021-01-21

What is the solubility of this product?

Asked by: hawkeye11
Thank you for your question. We recommend dissolving in DMSO. At room temperature, it is soluble up to 100 mg/ml. In water and ethanol, its solubility is 1 mg/ml. It is also soluble in a 1:4 mixture of HCl:EtOH at 10 mg/ml. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2019-03-13

Can I put  L-3,3′,5-Triiodothyronine, Sodium Salt to RGC culture media?

Asked by: Tianwen
Thank you for your question. This product, L-3,3′,5-Triiodothyronine, Sodium Salt: sc-205725, has not been specifically tested for cell culture use and is not cell culture grade, however, most products can still be used in cell culture applications by following basic cell culture protocols, e.g. using cell culture grade/sterilized solvents, aseptic technique, and sterilely filtering in a sterile hood. Please call our Technical Service department for further questions at (800) 457-3801 option 2, email scbt@scbt.com, or contact us by live chat.
Answered by: Technical Support
Date published: 2017-05-19
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Rated 5 out of 5 by from Videla LA; et alVidela LA; et al. (PubMed ID: 22649286)Determined that L-3,3 ,5-Triiodothyronine, Sodium Salt, a nuclear factor-E2-related factor 2 (Nrf2) in rat liver, was inhibited by apocynin and greatly reduced liver Nrf2 activation and HO-1 expression. -SCBT Publication Review
Date published: 2015-07-05
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L-3,3′,5-Triiodothyronine, Sodium Salt is rated 5.0 out of 5 by 1.
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