USP45 Activators
The chemical class termed USP45 Activators includes compounds that influence the cellular proteostasis network, mainly through the induction of proteotoxic stress or inhibition of protein degradation pathways, which can subsequently affect USP45 activity. These chemicals are not direct activators but operate by altering the cellular environment to potentially increase the functional demand for USP45's deubiquitinating activity.
For instance, proteasome inhibitors such as MG132, Bortezomib, and Epoxomicin increase the level of ubiquitinated proteins within the cell. This accumulation can create a need for enhanced deubiquitinating activity to restore protein homeostasis, potentially leading to an increased requirement for enzymes like USP45. These compounds achieve this by blocking the proteasome's ability to degrade polyubiquitinated proteins, which in turn could signal the cell to upregulate DUBs to remove the excess ubiquitin from proteins slated for degradation. Moreover, molecules that induce cellular stress responses, like Betulinic acid, Withaferin A, Tunicamycin, Thapsigargin, Disulfiram, 17-AAG, Celastrol, and Salubrinal, can also affect USP45 indirectly. They exert their influence by triggering the unfolded protein response or heat shock response, which may lead to an upregulation of various components of the protein quality control machinery, including DUBs such as USP45.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor that leads to the accumulation of ubiquitinated proteins, potentially increasing the demand for USP45's deubiquitinating activity. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Another proteasome inhibitor that can indirectly enhance USP45 activity by increasing ubiquitin-protein conjugates within the cell. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
A selective proteasome inhibitor, which can lead to an increase in ubiquitinated substrates, potentially stimulating USP45 activity. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
This pentacyclic triterpenoid induces endoplasmic reticulum stress and can lead to the activation of the unfolded protein response (UPR), which may indirectly enhance USP45 expression or activity as part of the cellular stress response. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
A steroidal lactone that induces proteotoxic stress, potentially enhancing the expression of DUBs like USP45 as part of a compensatory cellular response. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
An autophagy inhibitor that can lead to the accumulation of autophagic substrates and may upregulate USP45 indirectly due to increased protein turnover demands. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
An N-linked glycosylation inhibitor that triggers UPR and could lead to an increased demand for USP45 activity in the process of managing misfolded or unprocessed proteins. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
A sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump inhibitor that induces ER stress and could promote USP45 activity indirectly by enhancing the UPR. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
An irreversible inhibitor of aldehyde dehydrogenase that can cause cellular stress, potentially leading to an increase in USP45 expression or activity. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
An Hsp90 inhibitor that can lead to an increase in misfolded proteins, possibly necessitating increased USP45 activity to maintain protein quality control. | ||||||