USP45 Antibody (MA44): sc-130478
- USP45 Antibody (MA44) is a mouse monoclonal IgG2a κ USP45 antibody provided at 100 µg/ml
- raised against recombinant USP45 of human origin
- recommended for detection of USP45 of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for USP45 Antibody (MA44). This work is in progress.
USP45 Antibody (MA44) is a mouse monoclonal IgG2a kappa light chain antibody that detects the USP45 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-USP45 antibody (MA44) is available as a non-conjugated format. USP45, also known as Ubiquitin carboxyl-terminal hydrolase 45, is a crucial enzyme in the ubiquitin-proteasome system, which plays a significant role in regulating protein degradation and cellular homeostasis. This 819 amino acid protein is unique among ubiquitin-specific peptidases due to the presence of a UBP-type zinc finger domain that facilitates binding to ubiquitin, thereby enhancing deubiquitinating activity. USP45′s ability to remove ubiquitin from substrates is vital for controlling various cellular processes, including cell cycle progression, DNA repair, and response to stress. Notably, USP45 is predominantly expressed in skeletal muscle, spleen, and ovary, indicating potential involvement in tissue-specific functions. Alternative splicing of USP45 results in three distinct isoforms, which may have unique regulatory roles in cellular signaling pathways. With essential function in maintaining protein homeostasis, USP45 is a key player in cellular health and disease, making USP45 (MA44) monoclonal antibody an invaluable tool for researchers studying ubiquitin-mediated processes.
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USP45 Antibody (MA44) References:
- Human and mouse proteases: a comparative genomic approach. | Puente, XS., et al. 2003. Nat Rev Genet. 4: 544-58. PMID: 12838346
- Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. | Quesada, V., et al. 2004. Biochem Biophys Res Commun. 314: 54-62. PMID: 14715245
- Ubiquitin-binding domains. | Hicke, L., et al. 2005. Nat Rev Mol Cell Biol. 6: 610-21. PMID: 16064137
- Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. | Stegmeier, F., et al. 2007. Nature. 446: 876-81. PMID: 17443180
- The solution structure of the ZnF UBP domain of USP33/VDU1. | Allen, MD. and Bycroft, M. 2007. Protein Sci. 16: 2072-5. PMID: 17766394
- Structures of proteases for ubiqutin and ubiquitin-like modifiers. | Ha, BH. and Kim, EE. 2008. BMB Rep. 41: 435-43. PMID: 18593526
- Protein partners of deubiquitinating enzymes. | Ventii, KH. and Wilkinson, KD. 2008. Biochem J. 414: 161-75. PMID: 18687060
- USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses. | Perez-Oliva, AB., et al. 2015. EMBO J. 34: 326-43. PMID: 25538220
- USP45 and Spindly are part of the same complex implicated in cell migration. | Conte, C., et al. 2018. Sci Rep. 8: 14375. PMID: 30258100
- Comprehensive Analysis Reveals USP45 as a Novel Putative Oncogene in Pan-Cancer. | Li, K., et al. 2022. Front Mol Biosci. 9: 886904. PMID: 35836933
- Suppression of Cancer Cell Stemness and Drug Resistance via MYC Destabilization by Deubiquitinase USP45 Inhibition with a Natural Small Molecule. | Tu, X., et al. 2023. Cancers (Basel). 15: PMID: 36765885
- MYH10 Combines with MYH9 to Recruit USP45 by Deubiquitinating Snail and Promotes Serous Ovarian Cancer Carcinogenesis, Progression, and Cisplatin Resistance. | Liu, L., et al. 2023. Adv Sci (Weinh). 10: e2203423. PMID: 36929633
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
USP45 Antibody (MA44) | sc-130478 | 100 µg/ml | $339.00 |