UNCX Inhibitors
The UNCX inhibitors described herein are chemicals intended to target signaling pathways where the UNCX protein may participate. These inhibitors predominantly target major cellular pathways such as Wnt, Notch, and TGF-β signaling. Wnt pathway inhibitors like Wnt-C59 and IWP-2 act by targeting the Porcupine protein, thereby affecting lipid modification of Wnt proteins. XAV939 and BIO target the Wnt/β-catenin pathway. UNCX, which has roles in development and possibly cell differentiation, can be influenced by these inhibitors, thus warranting their classification under this chemical category.
Another subset of UNCX inhibitors focuses on influencing pathways related to cellular differentiation and tissue development. LY294002, a PI3K inhibitor, and SB431542, a TGF-β receptor inhibitor, fall into this category. These chemicals can disturb the balance of survival signals and developmental cues, wherein UNCX could be a factor. Also, MEK inhibitors like PD98059 and U0126 have been included given their impact on the ERK pathway, which may interact with UNCX's roles. This chemical class is functionally versatile, focusing on multiple nodes of signaling pathways where UNCX might serve as a mediator or effector.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $210.00 $320.00 $1250.00 | 1 | |
Inhibits the Wnt pathway by targeting Porcupine, a membrane-bound O-acyltransferase. This inhibition can influence the role of UNCX in developmental processes. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
Inhibits gamma-secretase, affecting Notch signaling, which may intersect with UNCX activity. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
Inhibits Porcupine, which is crucial for Wnt signaling, thereby affecting processes where UNCX may be involved. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that can influence cell survival and migration, thereby affecting UNCX. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A MEK inhibitor affecting the ERK pathway, where UNCX may have downstream effects. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
TGF-β receptor inhibitor that can disrupt processes in which UNCX is a player. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
Wnt/β-catenin pathway inhibitor that may affect the role of UNCX in cellular differentiation. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $153.00 $520.00 | 4 | |
GSK-3β inhibitor which activates Wnt signaling, thereby affecting UNCX's role in development. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor that may impede processes where UNCX may be a downstream effector. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
Inhibits GSK-3, affecting Wnt signaling, and thereby influencing UNCX’s roles. | ||||||