UGT2B Inhibitors
The chemical class of UGT2B Inhibitors includes compounds that indirectly modulate the function of UGT2B by affecting glucuronidation and related metabolic pathways. These inhibitors do not directly target UGT2B but influence the enzymatic activity and cellular environment in which UGT2B operates.Compounds such as Probenecid, Ketoprofen, Indomethacin, Fluconazole, Sulfinpyrazone, Isoniazid, Chloramphenicol, Gemfibrozil, and Piperine are known to interact with or inhibit glucuronidation enzymes. These interactions can disrupt the normal function of UGT2B in drug metabolism and detoxification processes. For instance, Probenecid and Indomethacin are noted for their ability to interfere with the glucuronidation process, which is a key function of UGT2B.
Other inhibitors, including Atazanavir, Crizotinib, and Lovastatin, affect different aspects of metabolic pathways and enzyme activities. Atazanavir and Crizotinib, through their actions as a protease inhibitor and an ALK inhibitor respectively, can indirectly modulate UGT2B's activity by influencing the metabolic processing of compounds. Lovastatin, known for its role in inhibiting cholesterol synthesis, might also impact UGT2B indirectly through lipid metabolism pathways.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $28.00 $39.00 $100.00 $277.00 | 28 | |
Known to inhibit glucuronidation, potentially affecting UGT2B activity. | ||||||
Ketoprofen | 22071-15-4 | sc-205359 sc-205359A | 5 g 25 g | $126.00 $339.00 | 2 | |
NSAID that can interfere with glucuronidation, potentially impacting UGT2B. | ||||||
Atazanavir | 198904-31-3 | sc-207305 | 5 mg | $292.00 | 7 | |
HIV protease inhibitor, known to inhibit UGT enzymes, possibly affecting UGT2B. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
NSAID that can inhibit glucuronidation enzymes, potentially impacting UGT2B. | ||||||
Fluconazole | 86386-73-4 | sc-205698 sc-205698A | 500 mg 1 g | $54.00 $84.00 | 14 | |
Antifungal, known to interact with glucuronidation enzymes, potentially affecting UGT2B. | ||||||
(±)-Sulfinpyrazone | 57-96-5 | sc-202822 sc-202822A | 1 g 5 g | $42.00 $94.00 | 2 | |
A uricosuric drug that can inhibit UGT enzymes, possibly impacting UGT2B. | ||||||
Isoniazid | 54-85-3 | sc-205722 sc-205722A sc-205722B | 5 g 50 g 100 g | $26.00 $101.00 $146.00 | ||
Can inhibit glucuronidation, potentially affecting UGT2B. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
Inhibits HMG-CoA reductase, potentially influencing UGT2B through lipid metabolism pathways. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $90.00 | 10 | |
Antibiotic known to inhibit various UGT enzymes, potentially affecting UGT2B. | ||||||
Gemfibrozil | 25812-30-0 | sc-204764 sc-204764A | 5 g 25 g | $66.00 $267.00 | 2 | |
Lipid-regulating agent that can inhibit UGT enzymes, potentially impacting UGT2B. | ||||||