UGT2B Antibody (E-6): sc-271777

UGT2B Antibody (E-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects UGT2B protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-UGT2B antibody (E-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. UGT2B plays a crucial role in the glucuronidation process, which is essential for the metabolism and detoxification of a wide array of endogenous and exogenous compounds. By catalyzing the addition of glucuronic acid to lipophilic molecules, UGT2B enhances their solubility, facilitating their excretion from the body and thereby reducing potential toxicity. This enzymatic activity is particularly important in the liver, where UGT2B isoenzymes are predominantly expressed, but these isoenzymes are also found in other tissues such as skin, breast, prostate, intestine, placenta, and lung. UGT2B′s ability to modulate the metabolism of steroids, bile acids, and xenobiotics underscores its significance in pharmacology and toxicology, making UGT2B (E-6) monoclonal antibody a valuable tool for researchers studying drug metabolism and the biological effects of various compounds. The human UGT2B genes are clustered on chromosome 4q13, highlighting their evolutionary relationship and functional interdependence.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

UGT2B Antibody (E-6) References:

1. Characterization and substrate specificity of UGT2B4 (E458): a UDP-glucuronosyltransferase encoded by a polymorphic gene.  |  Lévesque, E., et al. 1999. Pharmacogenetics. 9: 207-16. PMID: 10376768
2. Prevalence of polymorphisms in the human UDP-glucuronosyltransferase 2B family: UGT2B4(D458E), UGT2B7(H268Y), and UGT2B15(D85Y).  |  Lampe, JW., et al. 2000. Cancer Epidemiol Biomarkers Prev. 9: 329-33. PMID: 10750673
3. Expression of UGT2B7, a UDP-glucuronosyltransferase implicated in the metabolism of 4-hydroxyestrone and all-trans retinoic acid, in normal human breast parenchyma and in invasive and in situ breast cancers.  |  Gestl, SA., et al. 2002. Am J Pathol. 160: 1467-79. PMID: 11943730
4. SNP discovery, expression and cis-regulatory variation in the UGT2B genes.  |  Sun, C., et al. 2012. Pharmacogenomics J. 12: 287-96. PMID: 21358749
5. UGT2B gene expression analysis in multiple tobacco carcinogen-targeted tissues.  |  Jones, NR. and Lazarus, P. 2014. Drug Metab Dispos. 42: 529-36. PMID: 24459179
6. Regulation of UGT2B Expression and Activity by miR-216b-5p in Liver Cancer Cell Lines.  |  Dluzen, DF., et al. 2016. J Pharmacol Exp Ther. 359: 182-93. PMID: 27474751
7. The nuclear receptor Shp regulates morphine withdrawal syndrome via modulation of Ugt2b expression in mice.  |  Chen, M., et al. 2019. Biochem Pharmacol. 161: 163-172. PMID: 30689982
8. Effects of a Novel UGT2B Haplotype and UGT1A4*3 Allele Variants on Glucuronidation of Clozapine In vivo.  |  Smith, RL., et al. 2022. Curr Drug Metab. 23: 66-72. PMID: 35105285
9. Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13.  |  Monaghan, G., et al. 1994. Genomics. 23: 496-9. PMID: 7835904
10. Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids.  |  Beaulieu, M., et al. 1996. J Biol Chem. 271: 22855-62. PMID: 8798464
11. Isolation and characterization of a human orphan UDP-glucuronosyltransferase, UGT2B11.  |  Beaulieu, M., et al. 1998. Biochem Biophys Res Commun. 248: 44-50. PMID: 9675083
12. Characterization and regulation of UDP-glucuronosyltransferases in steroid target tissues.  |  Bélanger, A., et al. 1998. J Steroid Biochem Mol Biol. 65: 301-10. PMID: 9699884

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-UGT2B Antibody (E-6) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-UGT2B Antibody (E-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

UGT2B Antibody (E-6) Specifications

Alternate Product Name: UGT2B

Product Clone Name: E-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 188-487

Epitope Target: UGT2B

Epitope Species: human

Product Reactivity/Detection: UGT2B family members and UGT2A1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for UGT2B Antibody (E-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin