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Atazanavir is a highly potent HIV-1 protease inhibitor. Has shown to be generally more potent than the five currently approved HIV-1 Prt inhibitors. Atazanavir (BMS-232632) inhibited the proteolytic cleavage of the viral gag precursor p55 polyprotein in a dose-dependent manner, with a EC 50 of approximately 47 nM. Also highly selective for HIV-1 Prt and exhibits cytotoxicity only at concentrations 6,500- to 23,000-fold higher than that required for anti-HIV activity. Atazanavir (BMS-232632) may be an effective HIV-1 inhibitor that may be utilized in a variety of different drug combinations.
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See how others have used Atazanavir. Click on the entry to view the PubMed entry .
PMID: # 27249967 Costa, S. et al. 2016. Parasitology research.
PMID: # 26189431 Mendonza, A. et al. 2016. J Clin Pharmacol. 56: 355-64.
PMID: # 25815168 Hara, M. et al. 2015. Clin Kidney J. 8: 137-42.
PMID: # 23750830 Chang, JH. et al. 2013. Mol. Pharm. 10: 3067-75.
PMID: # 21068005 Leroyer, S. et al. 2011. J. Lipid Res. 52: 207-20.
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