Isoniazid is a front-line antituberculosis agent. Generates nitric oxide when activated by KatG. Isoniazid is also a strong inhibitor of DPH metabolism. This compound is both an inhibitor and inducer of various isoforms of cytochrome P450, a family of enzymes extensively involved in the metabolism of xenobiotics. CYP isoforms induced by this product include CYP2E1. Isoniazid reversibly inhibits CYP2C19 and CYP3A4 and inactivates CYP1A2 and CYP2A6.
Timmins GS, Master S, Rusnak F et al. J Bacteriol. 186:5427-31 (2004). Kutt H. Epilepsia. 16:393-402 (1975).
Soluble in water (50 mg/ml), ethanol (27 mg/ml at 25° C), DMSO (27 mg/ml at 25° C), and methanol.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Stettner et alStettner et al. (PubMed ID 26355945) found that isoniazid led to polyneuropathy in tuberculosis patients caused by the acetylation of NAT2. -SCBT Publication Review
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