TXA2R Activators
SEE ALSO...
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $90.00 $235.00 $4243.00 | 9 | |
Arachidonic Acid is a polyunsaturated fatty acid released from membrane phospholipids by phospholipase A2. It serves as a precursor to numerous eicosanoids, which are signaling molecules, including thromboxanes via the COX pathway. Thromboxane A2 (TXA2) is a product of arachidonic acid metabolism and can bind to TXA2R, thus activating it. | ||||||
8-epi-Prostaglandin F2α | 27415-26-5 | sc-201261 sc-201261A sc-201261B | 1 mg 5 mg 10 mg | $196.00 $871.00 $1443.00 | 2 | |
8-epi-Prostaglandin F2α acts as a potent agonist at the thromboxane A2 receptor (TXA2R), engaging in specific molecular interactions that trigger intracellular signaling cascades. Its unique stereochemistry allows for selective binding, influencing platelet aggregation and vascular tone. The compound's kinetics reveal a rapid onset of action, modulating downstream effects on smooth muscle contraction and inflammatory responses, thereby elucidating its role in cellular communication and homeostasis. | ||||||
PGB2 (Prostaglandin B2) | 13367-85-6 | sc-201219 sc-201219A | 1 mg 10 mg | $71.00 $352.00 | 1 | |
PGB2, a notable prostaglandin, exhibits unique interactions with the thromboxane A2 receptor (TXA2R), facilitating distinct signaling pathways. Its structural conformation enhances receptor affinity, leading to pronounced effects on cellular processes such as vasoconstriction and platelet activation. The compound's dynamic reaction kinetics contribute to its rapid biological effects, influencing various physiological responses and highlighting its role in modulating vascular and immune functions. | ||||||
8-iso Prostaglandin F2α-d4 | 211105-40-7 | sc-205174 sc-205174A | 25 µg 50 µg | $215.00 $533.00 | 1 | |
8-iso Prostaglandin F2α-d4 is a potent ligand for the thromboxane A2 receptor (TXA2R), characterized by its unique stereochemistry that influences receptor binding dynamics. This compound engages in specific molecular interactions that stabilize the TXA2R, triggering downstream signaling cascades. Its distinct conformational flexibility allows for rapid receptor activation, impacting cellular responses such as smooth muscle contraction and inflammatory processes, thereby underscoring its role in vascular homeostasis. | ||||||
U-46619 | 56985-40-1 | sc-201242 sc-201242A | 1 mg 10 mg | $240.00 $1275.00 | 40 | |
U46619 is a stable analog of TXA2. It is a potent and selective agonist of the thromboxane-prostanoid (TP) receptor, which includes TXA2R. As such, it can directly activate TXA2R by mimicking the natural ligand, TXA2. | ||||||
U-44069 | 56985-32-1 | sc-202848 sc-202848A | 1 mg 5 mg | $151.00 $667.00 | ||
U-44069 is a selective agonist for the thromboxane A2 receptor (TXA2R), exhibiting unique binding affinity due to its tailored molecular structure. This compound facilitates specific hydrogen bonding and hydrophobic interactions with TXA2R, enhancing receptor activation efficiency. Its kinetic profile reveals rapid onset and sustained engagement, promoting significant intracellular signaling pathways. The compound's distinct conformational adaptability further influences its interaction dynamics, contributing to its role in modulating vascular tone and platelet aggregation. | ||||||
U-51605 | 64192-56-9 | sc-205535 sc-205535A | 500 µg 1 mg | $309.00 $544.00 | ||
U-51605 acts as a selective antagonist for the thromboxane A2 receptor (TXA2R), characterized by its unique steric configuration that disrupts receptor-ligand interactions. This compound exhibits a high degree of specificity, allowing it to effectively block TXA2R-mediated signaling pathways. Its reaction kinetics indicate a slow dissociation rate, leading to prolonged receptor inhibition. Additionally, U-51605's molecular flexibility enhances its ability to stabilize inactive receptor conformations, thereby influencing downstream cellular responses. | ||||||
5-cis Carbaprostacyclin | 69609-77-4 | sc-205134 sc-205134A | 1 mg 5 mg | $236.00 $1120.00 | ||
Carbaprostacyclin is an analog of prostacyclin (PGI2). It preferentially activates the IP receptor but can also interact with TP receptors, including TXA2R, especially at higher concentrations or when IP receptors are blocked or desensitized. | ||||||
Prostaglandin B2-d4 | sc-224214A sc-224214 | 50 µg 100 µg | $67.00 $95.00 | |||
Prostaglandin B2-d4 serves as a potent modulator of the thromboxane A2 receptor (TXA2R), distinguished by its isotopic labeling that allows for precise tracking in biochemical assays. This compound engages in unique hydrogen bonding interactions, enhancing its affinity for TXA2R. Its dynamic conformation facilitates rapid receptor activation, while its distinct isotopic signature aids in elucidating receptor dynamics and downstream signaling cascades in experimental settings. | ||||||
5-trans U-46619 | 330796-58-2 | sc-223708 sc-223708A | 1 mg 5 mg | $117.00 $467.00 | ||
5-trans U-46619 is a selective agonist of the thromboxane A2 receptor (TXA2R), characterized by its unique structural conformation that promotes specific receptor binding. This compound exhibits distinct hydrophobic interactions, which enhance its stability in lipid environments. Its kinetic profile reveals a rapid onset of action, influencing downstream signaling pathways. Additionally, its ability to modulate receptor desensitization provides insights into receptor regulation mechanisms. | ||||||