Molecular structure of 5-cis Carbaprostacyclin, CAS Number: 69609-77-4
5-cis Carbaprostacyclin (CAS 69609-77-4)
Alternate Names:
6,9α-methylene-11α,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid; (5Z)-6a-Carbaprostaglandin I2
Application:
5-cis Carbaprostacyclin is n isomer of carbaprostacyclin which acts as a stable analog of PGI2
CAS Number:
69609-77-4
Molecular Weight:
350.5
Molecular Formula:
C21H34O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A stable analog of PGI2 and an isomer of carbaprostacyclin. It is a weak inhibitor of human platelet aggregation with an IC50 of 2.8 µM compared to 0.3 µM for carbaprostacyclin.1,2 5-cis Carbaprostacyclin is a much weaker effector of rabbit mesenteric artery relaxation with an EC50 of 104 µM compared to 5.9 µM for carbaprostacyclin. It even antagonizes the adenylate cyclase activation induced by carbaprostacyclin.2
5-cis Carbaprostacyclin (CAS 69609-77-4) References
- Vasoconstriction induced by activation of EP1 and EP3 receptors in human lung: effects of ONO-AE-248, ONO-DI-004, ONO-8711 or ONO-8713. | Norel, X., et al. 2004. Prostaglandins Other Lipid Mediat. 74: 101-12. PMID: 15560119
- Novel Endogenous Ligands of Aryl Hydrocarbon Receptor Mediate Neural Development and Differentiation of Neuroblastoma. | Wu, PY., et al. 2019. ACS Chem Neurosci. 10: 4031-4042. PMID: 31404492
- (5Z)-carbacyclin discriminates between prostacyclin-receptors coupled to adenylate cyclase in vascular smooth muscle and platelets. | Corsini, A., et al. 1987. Br J Pharmacol. 90: 255-61. PMID: 3545351
- Effects of Danggui Buxue decoction on host gut microbiota and metabolism in GK rats with type 2 diabetes. | Wang, WK., et al. 2022. Front Microbiol. 13: 1029409. PMID: 36353458
- Gut microbiota and metabolites in estrus cycle and their changes in a menopausal transition rat model with typical neuroendocrine aging. | Dai, R., et al. 2023. Front Endocrinol (Lausanne). 14: 1282694. PMID: 38161977
- Carbacyclin--a potent stable prostacyclin analogue for the inhibition of platelet aggregation. | Whittle, BJ., et al. 1980. Prostaglandins. 19: 605-27. PMID: 6992234
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TXA2R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-cis Carbaprostacyclin, 1 mg | sc-205134 | 1 mg | $236.00 | |||
5-cis Carbaprostacyclin, 5 mg | sc-205134A | 5 mg | $1120.00 |