Molecular structure of 5-trans U-46619, CAS Number: 330796-58-2
5-trans U-46619 (CAS 330796-58-2)
Alternate Names:
7-[(2S,3R)-3-[(3S)-3-hydroxyoct-1-enyl]-5oxabicyclo[2.2.1]heptan-2-yl]hept-5enoic acid
Application:
5-trans U-46619 is a TXA2R (Prostaglandin H2/thromboxane A2 receptor) agonist
CAS Number:
330796-58-2
Molecular Weight:
350.5
Molecular Formula:
C21H34O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
U-46619 is a TP receptor agonist that exhibits properties similar to Thromboxane A2, inducing platelet aggregation and vascular smooth muscle contraction(1,2). This is a minor impurity (2-5%) that is variably present in most commercial preparations of U-46619. The biological activity of 5-trans U-46619 has rarely been tested separately from U-46619 itself. The only case published to date, 5-trans U-46619 was found to be half as potent of an inhibitor of Prostaglandin E synthase as the 5-cis version of U-46619.3
5-trans U-46619 (CAS 330796-58-2) References
- Early events in fibroblast adhesion to glass. An electron microscopic study. | Pegrum, SM. and Maroudas, NG. 1975. Exp Cell Res. 96: 416-22. PMID: 1193185
- Binding of a thromboxane A2/prostaglandin H2 agonist [3H]U46619 to washed human platelets. | Liel, N., et al. 1987. Prostaglandins. 33: 789-97. PMID: 2959986
- Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations. | Coleman, RA., et al. 1981. Br J Pharmacol. 73: 773-8. PMID: 7248665
Activator of:
TXA2R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-trans U-46619, 1 mg | sc-223708 | 1 mg | $117.00 | |||
5-trans U-46619, 5 mg | sc-223708A | 5 mg | $467.00 |