TXA2R Inhibitors
SEE ALSO...
Items 1 to 10 of 15 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Prostaglandin I2 sodium | 61849-14-7 | sc-201231 sc-201231B sc-201231A sc-201231C sc-201231D sc-201231E | 1 mg 5 mg 10 mg 25 mg 100 mg 250 mg | $100.00 $417.00 $688.00 $1592.00 $5824.00 $12250.00 | 3 | |
Prostaglandin I2 sodium acts as a potent antagonist at the thromboxane A2 receptor (TXA2R), showcasing a unique ability to disrupt TXA2-mediated signaling. Its molecular structure facilitates specific hydrogen bonding interactions, which can alter receptor conformation. The compound exhibits a notable affinity for lipid bilayers, influencing membrane fluidity. Furthermore, its reaction kinetics indicate a slower dissociation rate, allowing prolonged receptor engagement and modulation of cellular responses. | ||||||
L-655,240 | 103253-15-2 | sc-201350 sc-201350A | 1 mg 5 mg | $57.00 $229.00 | ||
L-655,240 is a selective antagonist of the thromboxane A2 receptor (TXA2R), characterized by its ability to stabilize receptor conformations through unique hydrophobic interactions. This compound exhibits a distinct binding profile, favoring specific allosteric sites that modulate receptor activity. Its kinetic properties reveal a rapid association rate, leading to efficient receptor occupancy. Additionally, L-655,240 influences downstream signaling pathways, impacting cellular calcium dynamics and gene expression. | ||||||
U-51605 | 64192-56-9 | sc-205535 sc-205535A | 500 µg 1 mg | $309.00 $544.00 | ||
U-51605 acts as a selective antagonist of the thromboxane A2 receptor (TXA2R), distinguished by its unique ability to form hydrogen bonds with key amino acid residues, enhancing binding affinity. This compound demonstrates a slow dissociation rate, prolonging receptor inhibition. Its interaction with TXA2R alters conformational dynamics, influencing G-protein coupling efficiency and downstream signaling cascades, ultimately affecting cellular responses and metabolic pathways. | ||||||
Seratrodast | 112665-43-7 | sc-201352 sc-201352A | 10 mg 50 mg | $67.00 $373.00 | ||
Seratrodast is a TP receptor antagonist. It works by binding to TXA2R and blocking the binding of TXA2, thus preventing the activation of the receptor. | ||||||
PTA2 (Pinane thromboxane A2) | 71111-01-8 | sc-201177 | 1 mg | $200.00 | ||
PTA2 is a potent agonist of the thromboxane A2 receptor (TXA2R), characterized by its ability to induce conformational changes in the receptor structure. This compound exhibits rapid kinetics in receptor activation, leading to swift downstream signaling events. Its unique hydrophobic interactions with the receptor's binding pocket enhance specificity, while its influence on calcium mobilization and platelet aggregation underscores its role in modulating vascular responses. | ||||||
ICI 192,605 | 117621-64-4 | sc-361209 sc-361209A | 5 mg 25 mg | $90.00 $345.00 | 1 | |
ICI 192,605 is a selective antagonist of the thromboxane A2 receptor (TXA2R), known for its ability to stabilize the inactive conformation of the receptor. This compound exhibits a unique binding affinity that disrupts TXA2-mediated signaling pathways, effectively inhibiting downstream effects such as vasoconstriction and platelet activation. Its distinct molecular interactions involve hydrogen bonding and hydrophobic contacts, contributing to its specificity and efficacy in receptor modulation. | ||||||
BAY-u 3405 | 116649-85-5 | sc-203834 sc-203834A | 10 mg 50 mg | $189.00 $797.00 | ||
Ramatroban is a dual antagonist of the TP receptor and the CRTH2 receptor. It prevents the activation of TXA2R by blocking the binding of TXA2 to the receptor. | ||||||
BM 567 | 284464-77-3 | sc-205229 sc-205229A | 1 mg 5 mg | $72.00 $435.00 | 1 | |
BM 567 is a selective antagonist of the thromboxane A2 receptor (TXA2R), characterized by its ability to induce conformational changes in the receptor's structure. This compound engages in specific molecular interactions, including π-π stacking and van der Waals forces, which enhance its binding affinity. By modulating TXA2R activity, BM 567 influences intracellular signaling cascades, impacting various physiological processes without directly altering receptor expression levels. | ||||||
13-APA | 71629-07-7 | sc-223165 sc-223165A | 1 mg 10 mg | $65.00 $539.00 | ||
13-APA acts as a potent modulator of the thromboxane A2 receptor (TXA2R), exhibiting unique binding dynamics that facilitate allosteric regulation. Its structure allows for specific hydrogen bonding and hydrophobic interactions, which stabilize receptor conformations. This compound influences downstream signaling pathways by altering G-protein coupling efficiency, thereby fine-tuning cellular responses. The kinetics of its interaction suggest a rapid onset of action, highlighting its role in receptor modulation. | ||||||
Daltroban | 79094-20-5 | sc-214835 sc-214835A | 5 mg 25 mg | $195.00 $760.00 | 2 | |
Daltroban is a selective antagonist of the thromboxane A2 receptor (TXA2R), characterized by its ability to disrupt TXA2-mediated signaling. Its unique molecular architecture enables it to engage in specific electrostatic interactions with receptor sites, leading to conformational changes that inhibit receptor activation. The compound exhibits a distinct kinetic profile, with a notable affinity for the TXA2R, allowing for precise modulation of associated intracellular pathways and cellular responses. | ||||||