TXA2R Antibody (G-2): sc-515033

TXA2R Antibody (G-2) is a mouse monoclonal IgG3 kappa light chain antibody that detects TXA2R protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-TXA2R antibody (G-2) is available as the non-conjugated form. Thromboxane A2 (TXA2), a key product of arachidonic acid metabolism via cyclooxygenase (COX), plays a crucial role in various physiological processes, including platelet aggregation and vasoconstriction, making TXA2R vital for cardiovascular health. TXA2 receptor (TXA2R) is a G protein-coupled receptor that, upon activation, stimulates phospholipase C (PLC) to release intracellular calcium, which is essential for numerous cellular responses. TXA2R can activate the MAP kinase pathway in response to dibutyryl cyclic AMP (dbcAMP), further underscoring TXA2R′s importance in cellular signaling. The human TXA2R gene is located on chromosome 19p13.3 and undergoes alternative splicing, resulting in protein variants that differ in their carboxy termini, which may influence their functional properties. TXA2R is predominantly expressed in platelets, endothelial cells, the placenta, vascular smooth muscle, and the renal cortex, highlighting TXA2R′s diverse roles in both normal physiology and pathological conditions. Mutations in the TXA2R gene can lead to bleeding disorders due to dysfunctional receptor signaling, and TXA2R has been implicated in renal damage during disease states, as well as in the regulation of labor in women, indicating TXA2R′s potential as a therapeutic target in various clinical scenarios.

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TXA2R Antibody (G-2) References:

1. Internalization of the TXA2 receptor alpha and beta isoforms. Role of the differentially spliced cooh terminus in agonist-promoted receptor internalization.  |  Parent, JL., et al. 1999. J Biol Chem. 274: 8941-8. PMID: 10085139
2. [Thromboxane A2 receptor-mediated signal transduction in glial cells].  |  Nakahata, N., et al. 1998. Nihon Yakurigaku Zasshi. 112 Suppl 1: 113P-117P. PMID: 10190146
3. Coupling of thromboxane A2 receptor isoforms to Galpha13: effects on ligand binding and signalling.  |  Becker, KP., et al. 1999. Biochim Biophys Acta. 1450: 288-96. PMID: 10395940
4. Involvement of phosphatidylcholine-specific phospholipase C in thromboxane A2-induced activation of mitogen-activated protein kinase in astrocytoma cells.  |  Kobayashi, H., et al. 2000. J Neurochem. 74: 2167-73. PMID: 10800962
5. Thromboxane A2 receptor antagonist prevents pancreatic microvascular leakage in rats with caerulein-induced acute pancreatitis.  |  Hirano, T. and Hirano, K. 1999. Int J Surg Investig. 1: 203-10. PMID: 11341608
6. The expression of thromboxane A2 synthase and thromboxane A2 receptor gene in human uterus.  |  Swanson, ML., et al. 1992. Biol Reprod. 47: 105-17. PMID: 1386258
7. Revisiting the usefulness of thromboxane-A2 modulation in the treatment of bronchoconstriction in asthma.  |  Hernandez, JM. and Janssen, LJ. 2015. Can J Physiol Pharmacol. 93: 111-7. PMID: 25581104
8. Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor.  |  Raychowdhury, MK., et al. 1994. J Biol Chem. 269: 19256-61. PMID: 8034687
9. Cellular activation by thromboxane A2 and other eicosanoids.  |  Reilly, M. and Fitzgerald, GA. 1993. Eur Heart J. 14 Suppl K: 88-93. PMID: 8131796
10. Characterization and chromosomal mapping of the human thromboxane A2 receptor gene.  |  Nüsing, RM., et al. 1993. J Biol Chem. 268: 25253-9. PMID: 8227091
11. Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation.  |  Hirata, T., et al. 1996. J Clin Invest. 97: 949-56. PMID: 8613548
12. A genetic approach for studying the role of thromboxane A2 in the kidney.  |  Thomas, DW. and Coffman, TM. 1998. Kidney Int Suppl. 67: S84-7. PMID: 9736260

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TXA2R Antibody (G-2) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-TXA2R Antibody (G-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TXA2R Antibody (G-2) Specifications

Alternate Product Name: TXA2R

Product Clone Name: G-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 221-240

Epitope Target: TXA2R

Epitope Species: human

Product Reactivity/Detection: TXA2R long and short isoforms

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for TXA2R Antibody (G-2): P: Blocking Peptide