Molecular structure of U-51605, CAS Number: 64192-56-9
U-51605 (CAS 64192-56-9)
Application:
U-51605 is n inhibitor of both PGI and thromboxane synthases
CAS Number:
64192-56-9
Molecular Weight:
332.5
Molecular Formula:
C20H32N2O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A stable analog of the endoperoxide prostaglandin H2 (PGH2). An inhibitor of both PGI and thromboxane synthases with more selectivity towards PGI synthase. In human foreskin fibroblasts, U-51605 inhibits PGI synthase at a concentration of 2.8 µM,1 whereas, human platelet thromboxane synthase is inhibited at a concentration of 5.6 µM.2 U-51605 (0.1 µg/ml) also inhibits PGH2-induced human platelet aggregation.3
U-51605 (CAS 64192-56-9) References
1 Gorman, R.R., Hamilton, R.D., Hopkins, N.K. Stimulation of human foreskin fibroblast adenosine 3':5'-cyclic monophosphate levels by prostacyclin (prostaglandin I2). J Biol Chem 254 1671-1676 (1979). 2 Gorman, R.R., Bundy, G.L., Peterson, D.C., et al. Inhibition of human platelet thromboxane synthetase by 9,11-azoprosta-5,13-dienoic acid. Proc Natl Acad Sci USA 74 4007-4011 (1977). 3 Needleman, P., Bryan, B., Wyche, A., et al. Thromboxane synthetase inhibitors as pharmacological tools: Differential biochemical and biological effects on platelet suspensions. Prostaglandins 14 897-907 (1977).Inhibitor of:
PGI2, and TXA2R.Activator of:
TXA2R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
U-51605, 500 µg | sc-205535 | 500 µg | $309.00 | |||
U-51605, 1 mg | sc-205535A | 1 mg | $544.00 |