TTP-αL Activators
TTP-αL Activators are a class of compounds that enhance the functional activity of TTP-αL through direct or indirect interactions. They work through various signaling pathways that TTP-αL is directly involved in. Forskolin, IBMX, BAY 60-6583, Anandamide, Dibutyryl cAMP, and Prostaglandin E2 all work through the cAMP-PKA pathway. They influence the pathway by increasing the intracellular cAMP levels, which leads to the activation of PKA. PKA then phosphorylates proteins in the TTP-αL signaling pathway, enhancing its functional activity. This class of compounds illustrates how alteration in cAMP levels can directly influence the functional activity of TTP-αL.
Other activators like A23187 and Thapsigargin act by increasing intracellular calcium levels, which can activate calcium-dependent kinases that phosphorylate proteins in the TTP-αL signaling pathway. Phorbol 12-myristate 13-acetate (PMA) and Chelerythrine chloride, on the other hand, work through the protein kinase C (PKC) pathway, either activating or inhibiting PKC to alter the phosphorylation state of proteins in the TTP-αL pathway. L-NAME acts by inhibiting nitric oxide synthase, reducing nitric oxide levels, a molecule that can inhibit PKA. Genistein the dephosphorylation of proteins in the TTP-αL pathway, maintaining their active state.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of the enzyme adenylate cyclase, which increases intracellular levels of cAMP. The elevated cAMP can potentiate the activation of protein kinase A (PKA) leading to enhanced phosphorylation of proteins in the signaling pathway of TTP-αL. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX inhibits phosphodiesterase, an enzyme that degrades cAMP. This action increases cAMP levels, which in turn activates PKA, leading to an enhancement of the phosphorylation of proteins in the TTP-αL signaling pathway. | ||||||
BAY 60-6583 | 910487-58-0 | sc-503262 | 10 mg | $210.00 | ||
BAY 60-6583 is an agonist of the A2B adenosine receptor, which is known to increase cAMP levels upon activation. The increased cAMP activates PKA, which enhances the phosphorylation of proteins in the TTP-αL pathway. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular levels of calcium. The increased calcium levels can trigger the activation of calcium-dependent kinases that phosphorylate proteins in the TTP-αL signaling pathway. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl cAMP is a cell-permeable cAMP analog that can activate PKA, leading to enhanced phosphorylation of proteins in the TTP-αL signaling pathway. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a known activator of protein kinase C (PKC), which can phosphorylate proteins in the TTP-αL signaling pathway, leading to enhanced activity of TTP-αL. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
Chelerythrine chloride is a potent, selective, and cell-permeable protein kinase C inhibitor that can modulate the phosphorylation state of proteins in the TTP-αL pathway. The inhibition of PKC leads to an altered phosphorylation state of these proteins, which can enhance the activity of TTP-αL. | ||||||
L-NG-Nitroarginine Methyl Ester (L-NAME) | 51298-62-5 | sc-200333 sc-200333A sc-200333B | 1 g 5 g 25 g | $48.00 $107.00 $328.00 | 45 | |
L-NAME is an inhibitor of nitric oxide synthase, which reduces the levels of nitric oxide, a signaling molecule that can inhibit PKA. Reduced nitric oxide levels can lead to increased PKA activation and enhanced phosphorylation of proteins in the TTP-αL pathway. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can prevent the dephosphorylation of proteins in the TTP-αL pathway, maintaining their active phosphorylated state and enhancing TTP-αL activity. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 activates the prostaglandin E receptor, leading to elevated cAMP levels. The increased cAMP activates PKA, which enhances the phosphorylation of proteins in the TTP-αL pathway. | ||||||