TTLL9 Activators
TTLL9, short for Tubulin Tyrosine Ligase Like 9, is a protein in humans that is encoded by the TTLL9 gene. It belongs to the TTL domain protein family and is involved in the post-translational modification of tubulin. The primary function of TTLL9 is to catalyze the polyglutamylation of tubulin, which is the addition of glutamate chains to the gamma-carboxyl groups of glutamate residues in tubulin. This modification plays a critical role in the regulation of microtubules, which are key components of the cytoskeleton in eukaryotic cells.
Microtubules are dynamic structures that participate in various cellular processes such as mitosis, cytokinesis, vesicle transport, and the maintenance of cell shape and polarity. The polyglutamylation of tubulin by TTLL9 modulates the interaction between microtubules and microtubule-associated proteins (MAPs), affecting the stability and function of microtubules. Consequently, TTLL9 is implicated in the proper assembly and disassembly of microtubules, which is essential for cell division and motility.
The activity of TTLL9 is tightly regulated within the cell, and its dysfunction has been associated with certain pathological conditions. Understanding the specific roles of TTLL9 and its regulation is an area of active research, as it may provide insights into the mechanisms of microtubule-related diseases and targets.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
May affect TTLL9 expression through retinoic acid receptors, which regulate gene transcription in various cellular contexts. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Could induce gene expression by reducing DNA methylation, thus potentially affecting the expression of TTLL9. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As a histone deacetylase inhibitor, it may promote a more relaxed chromatin state, influencing TTLL9 expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
By raising cAMP levels, forskolin can modulate transcription factors that may increase TTLL9 expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This antioxidant could modify signaling pathways, possibly affecting the expression of genes like TTLL9. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Acts as a tyrosine kinase inhibitor, which might influence signaling pathways regulating TTLL9 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Known to modulate various cellular processes and may affect transcription factors controlling TTLL9 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Could influence gene expression by activating sirtuins, which may play a role in regulating TTLL9 expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Activates Nrf2, a transcription factor that might influence the expression of a variety of genes, including TTLL9. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $42.00 $62.00 $153.00 $255.00 $500.00 $30.00 | 37 | |
Through activation of AMPK, metformin might affect signaling pathways that regulate TTLL9 expression. | ||||||