TSPY3 Inhibitors
The chemical class of TSPY3 inhibitors encompasses compounds targeting key signaling pathways and cellular processes involved in the regulation of TSPY3 expression and activity. TSPY3 is a member of the Y chromosome-specific protein family associated with tumorigenesis and cancer progression.
One group of inhibitors includes those targeting the PI3K/AKT/mTOR pathway, which regulates cell growth, proliferation, and survival. Compounds like Wortmannin and Rapamycin inhibit PI3K and mTOR, respectively, leading to downstream effects on protein synthesis and cell growth, potentially suppressing TSPY3 expression by modulating cellular proliferation and survival pathways.
Another class of inhibitors includes those targeting stress response pathways, such as MAPK and JNK. Compounds like SB203580 and SP600125 inhibit MAPK and JNK, respectively, potentially influencing TSPY3 expression by modulating downstream signaling events involved in cellular stress responses and apoptosis.
Furthermore, inhibitors targeting kinase enzymes, such as MEK and JAK, modulate signaling cascades involved in cellular proliferation and survival, potentially impacting TSPY3 expression through downstream signaling events. Collectively, the chemical class of TSPY3 inhibitors provides valuable tools for investigating the molecular mechanisms underlying TSPY3 function.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $160.00 $345.00 | 12 | |
AZD8055 is an ATP-competitive inhibitor of the mammalian target of rapamycin (mTOR), blocking mTORC1 and mTORC2 complexes, which are involved in cell growth and proliferation pathways. By inhibiting mTOR, AZD8055 can indirectly suppress TSPY3 expression by modulating downstream signaling cascades. | ||||||
PD 169316 | 152121-53-4 | sc-204168 sc-204168A sc-204168B sc-204168C | 1 mg 5 mg 10 mg 25 mg | $86.00 $153.00 $275.00 $452.00 | 3 | |
SB202190 is a selective inhibitor of p38 mitogen-activated protein kinase (MAPK), a key regulator of inflammatory responses and cellular stress. By blocking p38 MAPK signaling, SB202190 can potentially influence TSPY3 expression indirectly through its effects on downstream transcriptional activities. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 is an inhibitor of nuclear factor-kappa B (NF-κB) activation, which plays a critical role in inflammation, immunity, and cell survival. Inhibition of NF-κB by BAY 11-7082 can indirectly impact TSPY3 expression by modulating the transcriptional regulation of target genes involved in cell proliferation. | ||||||
BIX 02189 | 1094614-85-3 | sc-364436 sc-364436A | 5 mg 10 mg | $220.00 $378.00 | 5 | |
BIX02189 is a selective inhibitor of mitogen-activated protein kinase kinase 3/6 (MKK3/6), upstream regulators of p38 MAPK signaling pathway. By blocking MKK3/6 activity, BIX02189 can potentially modulate downstream signaling cascades involved in cellular stress responses, thereby indirectly influencing TSPY3 expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of phosphoinositide 3-kinase (PI3K), a key regulator of cell growth, proliferation, and survival. Inhibition of PI3K by LY294002 can indirectly impact TSPY3 expression by modulating downstream signaling pathways involved in cellular growth and proliferation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is a selective inhibitor of c-Jun N-terminal kinase (JNK), a member of the MAPK family involved in cellular stress responses and apoptosis. By inhibiting JNK activity, SP600125 can indirectly regulate TSPY3 expression through its effects on downstream transcriptional activities and cell survival pathways. | ||||||
AG-490 | 133550-30-8 | sc-202046C sc-202046A sc-202046B sc-202046 | 5 mg 50 mg 25 mg 10 mg | $82.00 $323.00 $219.00 $85.00 | 35 | |
AG-490 is a Janus kinase (JAK) inhibitor that blocks JAK/STAT signaling, which regulates cell growth and immune responses. Inhibition of JAK by AG-490 can indirectly influence TSPY3 expression by modulating downstream transcriptional activities involved in cell growth and survival. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of mitogen-activated protein kinase kinase 1/2 (MEK1/2), upstream regulators of extracellular signal-regulated kinase (ERK) signaling pathway. By blocking MEK1/2 activity, U0126 can potentially modulate downstream signaling cascades involved in cellular proliferation and survival. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 mitogen-activated protein kinase (MAPK), a key regulator of inflammatory responses and cellular stress. By blocking p38 MAPK signaling, SB203580 can potentially influence TSPY3 expression indirectly through its effects on downstream transcriptional activities. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinase (PI3K), a key regulator of cell growth, proliferation, and survival. Inhibition of PI3K by Wortmannin can indirectly impact TSPY3 expression by modulating downstream signaling pathways involved in cellular growth and proliferation. | ||||||