Molecular structure of AG-490, CAS Number: 133550-30-8
AG-490 (CAS 133550-30-8)
See product citations (35)
Alternate Names:
Tyrphostin B42
Application:
AG-490 is a tyrosine kinase inhibitor of JAK2, EGFR, JAK3 and Neu
CAS Number:
133550-30-8
Purity:
≥98%
Molecular Weight:
294.30
Molecular Formula:
C17H14N2O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AG-490 is a tyrosine kinase inhibitor of JAK2, EGFR, and Neu that belongs to the family of tyrphostins. In acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors. Additionally, AG-490 has been observed to block cytokine-induced activation of JAK2 in eosinophils and STAT3 activation in T cell lymphoma cells. Unlike other kinase inhibitors, AG-490 does not inhibit JAK1, Lck, Btk, Tyk2, Syk, Lyn, and Src. Research indicates that AG-490 inhibits IL-7 mediated proliferation. Inhibition of Jak kinase activity by AG-490 leads to lower levels of p85 phosphorylation and p-13 kinase activation. AG-490 is an inhibitor of JAK3.
AG-490 (CAS 133550-30-8) References
- JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response. | Wang, LH., et al. 1999. J Immunol. 162: 3897-904. PMID: 10201908
- Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells. | Kirken, RA., et al. 1999. J Leukoc Biol. 65: 891-9. PMID: 10380915
- Blockade of JAK2 by tyrphostin AG-490 inhibits antigen-induced eosinophil recruitment into the mouse airways. | Kumano, K., et al. 2000. Biochem Biophys Res Commun. 270: 209-14. PMID: 10733929
- JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells. | De Vos, J., et al. 2000. Br J Haematol. 109: 823-8. PMID: 10929036
- JAK inhibitors AG-490 and WHI-P154 decrease IFN-gamma-induced iNOS expression and NO production in macrophages. | Sareila, O., et al. 2006. Mediators Inflamm. 2006: 16161. PMID: 16883061
- Tyrphostin AG-490 inhibited the acute phase of zymosan-induced inflammation. | Dimitrova, P. and Ivanovska, N. 2008. Int Immunopharmacol. 8: 1567-77. PMID: 18656556
- Inhibition of Janus kinases by tyrosine phosphorylation inhibitor, Tyrphostin AG-490. | Rashid, S., et al. 2015. J Biomol Struct Dyn. 33: 2368-79. PMID: 26017266
- [Intrathecal injection of AG-490 reduces bone-cancer-induced spinal cord astrocyte reaction and thermal hyperalgesia in a mouse model]. | Zhang, J., et al. 2018. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 43: 1182-1187. PMID: 30643061
- ESTAT3 Inhibitor AG-490 Inhibits the Growth of Prostate Cancer by miR-503-5p Both In Vivo and In Vitro. | Tan, G., et al. 2020. Technol Cancer Res Treat. 19: 1533033820948062. PMID: 33063634
- AG490 protects cerebral ischemia/reperfusion injury via inhibiting the JAK2/3 signaling pathway. | Fan, L. and Zhou, L. 2021. Brain Behav. 11: e01911. PMID: 33098244
- Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity. | Dadi, H., et al. 1994. Blood. 84: 1579-86. PMID: 7520779
- JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3' kinase. | Sharfe, N., et al. 1995. Blood. 86: 2077-85. PMID: 7662955
- Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. | Meydan, N., et al. 1996. Nature. 379: 645-8. PMID: 8628398
Inhibitor of:
1110006G06Rik, 1110007A13Rik, 1110008J03Rik, 1110012D08Rik, 1700022C21Rik, 1700023C21Rik, 1700027N10Rik, 1700090G07Rik, 1810020G14Rik, 1810029B16Rik, 2200001I15Rik, 4933412E14Rik, Ag2, BB146404, BC022651, BC023179, BC023882, BC025076, BC025816, BC026590, BC027231, BC030183, C-MIP, C5orf43, C6orf81, C78339, CD42d, CD96, CINC-1, CLEC-2B, CLEC-2E, Contrin, CRIP2, EGFL3, EGFR, Embigin, eoxtaxin-3, FAM26D, FAM46A, FCGBP_Fcgbp, FLJ10489, FRAS1, G6b_AU023871, GFOD2, HPA2c, ICAM-5, IFITM10, IFITM7, IFN-κ, IFN-τ, Insulin II, ISLR, JAK, JAK2, JAK3, KLRH1, KSP37, LOH11CR1A_AI593442, LRRC53, LRRC56, Ly6G6f, MAWDBP, MDL-1, Med12l, MrgA2a, MrgA7, netrin-2_netrin-3, Neu, NRBP, NTN, Olr63, p36, PCDGF, PID1, preY, Proliferin-3, R3HDM2, Reg IIIδ, SLITRK1, STAF42, Tenascin, TMEM136, TMEM149, TMUB2, Tomm20l, Trav3n-3, TSPY3, TTC4, Tyrosine Kinase, UNQ464, V3R 10, V3R 3, V3R 6, WARP, XAGE-1A, XAGE1E, ZNF237, ZNF687, and ZNF784.Activator of:
PID1, and POU3F4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AG-490, 5 mg | sc-202046C | 5 mg | $84.00 | |||
AG-490, 10 mg | sc-202046 | 10 mg | $87.00 | |||
AG-490, 25 mg | sc-202046B | 25 mg | $223.00 | |||
AG-490, 50 mg | sc-202046A | 50 mg | $329.00 |