PD 169316 CAS: 152121-53-4
MF: C20H13FN4O2
MW: 360.34
A potent and selective p38 MAP kinase inhibitor.

PD 169316 (CAS 152121-53-4)

PD 169316 | CAS 152121-53-4 is rated 5.0 out of 5 by 1.
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Synonym: 4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole; 4-[5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-4-yl]-pyridine
Application: A potent and selective p38 MAP kinase inhibitor
CAS Number: 152121-53-4
Purity: >98%
Molecular Weight: 360.34
Molecular Formula: C20H13FN4O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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PD 169316 is a potent, cell-permeable, and selective p38α (p38 MAP kinase) inhibitor (IC50 = 89 nM). Inhibition of p38α (p38 MAP kinase) by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.


References

1. Nath, R., et al. 2001. Cell Mol. Biol. Lett. 6: 173-184. PMID: 11544639
2. Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5: 49-64. PMID: 9043657
3. Kummer, J.L., et al. 1997. J. Biol. Chem. 272: 20490-20494. PMID: 9252360

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), DMF (~2 mg/ml), DMF:PBS (pH 7.2) 1:2 (~0.25 mg/ml), and methanol (slightly). Insoluble in water, ethyl acetate, and diethyl ether.
Storage :
Store at -20° C
Melting Point :
266.74° C (Predicted)
Boiling Point :
583.06° C at 760 mmHg (Predicted)
Density :
1.35 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
5-LO: IC50 = 50 nM (human); p38 MAP kinase: IC50 = 89 nM; Plasmodium falciparum: IC50 = 3.16 µM
pK Values :
pKb: 9.14 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
4712
MDL Number :
MFCD12405019
SMILES :
C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)[N+](=O)[O-]

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Certificate of Analysis

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PD 169316  Product Citations

See how others have used PD 169316. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 29355586  Ma, L.|Li, K.|Guo, Y.|Sun, X.|Deng, H.|Li, K.|Feng, Q.|Li, S.| et al. 2018. Biochim Biophys Acta Mol Cell Res. 1865: 560-571.

PMID: # 12801934  Wang, HY. et al. 2003. J. Biol. Chem. 278: 31547-31553.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Wang et Wang et.al. (PubMed ID # 12801934) found that PD169316 (Cas # 152121-53-4) was not successful in A 42-induced tau phosphorylation at concentrations considered safe for cell viability (serum starved SK-N-MC cells used). -SCBT Publication Review
Date published: 2015-02-17
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