Molecular structure of PD 169316, CAS Number: 152121-53-4
PD 169316 (CAS 152121-53-4)
See product citations (3)
Alternate Names:
4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole; 4-[5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-4-yl]-pyridine
Application:
PD 169316 is a potent and selective p38 MAP kinase inhibitor
CAS Number:
152121-53-4
Purity:
>98%
Molecular Weight:
360.34
Molecular Formula:
C20H13FN4O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PD 169316 is a potent, cell-permeable, and selective p38alpha (p38 MAP kinase) inhibitor (IC50 = 89 nM). Inhibition of p38alpha (p38 MAP kinase) by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines. PD 169316 is classified as a small-molecule inhibitor with high potency and selectivity towards p38alpha, a subtype of p38 mitogen-activated protein (MAP) kinases. With an inhibitory concentration 50 (IC50) value of 89 nM, it effectively impedes the kinase activity of p38alpha, which plays a critical role in the response to stress signals and inflammatory cytokines in cells. The p38 MAP kinase pathway is implicated in various cellular processes, including differentiation, apoptosis, and autophagy.
PD 169316 (CAS 152121-53-4) References
- High-intensity p38 kinase activity is critical for p21(cip1) induction and the antiproliferative function of G(i) protein-coupled receptors. | Alderton, F., et al. 2001. Mol Pharmacol. 59: 1119-28. PMID: 11306695
- Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27. | Kato, K., et al. 2001. Cell Stress Chaperones. 6: 16-20. PMID: 11525238
- Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons. | Nath, R., et al. 2001. Cell Mol Biol Lett. 6: 173-84. PMID: 11544639
- Thrombin stimulates dissociation and induction of HSP27 via p38 MAPK in vascular smooth muscle cells. | Hirade, K., et al. 2002. Am J Physiol Heart Circ Physiol. 283: H941-8. PMID: 12181122
- The lipid peroxidation end-product 4-HNE induces COX-2 expression through p38MAPK activation in 3T3-L1 adipose cell. | Zarrouki, B., et al. 2007. FEBS Lett. 581: 2394-400. PMID: 17481611
- Two High Throughput Screen Assays for Measurement of TNF-α in THP-1 Cells. | Leister, KP., et al. 2011. Curr Chem Genomics. 5: 21-9. PMID: 21643507
- p38 Mitogen-activated protein kinase modulates exocrine secretion in rabbit lacrimal gland. | Carlsson, SK. and Gierow, JP. 2012. Cell Mol Biol Lett. 17: 1-10. PMID: 22069054
- Bisphenol A exerts estrogenic effects by modulating CDK1/2 and p38 MAP kinase activity. | Lee, HS., et al. 2014. Biosci Biotechnol Biochem. 78: 1371-5. PMID: 25130739
- The p38 MAP kinase inhibitor, PD 169316, inhibits flagellar motility in Leishmania donovani. | Reddy, GS., et al. 2017. Biochem Biophys Res Commun. 493: 1425-1429. PMID: 28958943
- Tingenone and 22-hydroxytingenone target oxidative stress through downregulation of thioredoxin, leading to DNA double-strand break and JNK/p38-mediated apoptosis in acute myeloid leukemia HL-60 cells. | Rodrigues, ACBDC., et al. 2021. Biomed Pharmacother. 142: 112034. PMID: 34411914
- Targeting tumour-associated macrophages in hodgkin lymphoma using engineered extracellular matrix-mimicking cryogels. | Bahlmann, LC., et al. 2023. Biomaterials. 297: 122121. PMID: 37075613
- Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase. | Gallagher, TF., et al. 1997. Bioorg Med Chem. 5: 49-64. PMID: 9043657
- Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. | Kummer, JL., et al. 1997. J Biol Chem. 272: 20490-4. PMID: 9252360
Inhibitor of:
β-defensin 133, 4933412E24Rik, ACAM, ANKS4B, BC055107, BC057022, C-TAK1L, C230097I24Rik, Dendritic Cell marker, DXBay18, EG434396, EG435940, EG435946, EG435949, EG546901, EG626575, EG626682, EG626740, EG626970, EG667485, F8A1, FAM25G, FAM75A6, FLJ35220, Hog1, IL-14, LOC100041339, LOC100041371, LOC644191, LOC644477, LOC646285, MAPBPIP, MBOAT2, MEK3, MOAP1, MUP20, NELL2, NRADD, Nsg2, Oit1, Olfr71, Olfr710, Olfr711, Olfr922, OR4P4, p38, p38 alpha, Pelle, PRR25, RELL2, RINZF, Ser/Thr Protein Kinase, SWI5, syntenin-1, TSPY3, TTP, UNQ464, V1RC, Vmn1r120, Vmn1r122, Vmn1r151, Vmn1r92, ZBTB22, and ZNF726.Activator of:
BTNL10, Btnl6, CRX, D930020B18Rik, DPY19L2, ephrin-B1, Gbp9, OR1K1, and VibH.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PD 169316, 1 mg | sc-204168 | 1 mg | $88.00 | |||
PD 169316, 5 mg | sc-204168A | 5 mg | $156.00 | |||
PD 169316, 10 mg | sc-204168B | 10 mg | $281.00 | |||
PD 169316, 25 mg | sc-204168C | 25 mg | $461.00 |