PD 169316 is a potent, cell-permeable, and selective p38α (p38 MAP kinase) inhibitor (IC50 = 89 nM). Inhibition of p38α (p38 MAP kinase) by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.
1. Nath, R., et al. 2001. Cell Mol. Biol. Lett. 6: 173-184. PMID: 11544639 2. Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5: 49-64. PMID: 9043657 3. Kummer, J.L., et al. 1997. J. Biol. Chem. 272: 20490-20494. PMID: 9252360
Soluble in DMSO (10 mg/ml), DMF (~2 mg/ml), DMF:PBS (pH 7.2) 1:2 (~0.25 mg/ml), and methanol (slightly). Insoluble in water, ethyl acetate, and diethyl ether.
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Rated 5 out of
Wang etWang et.al. (PubMed ID # 12801934) found that PD169316 (Cas # 152121-53-4) was not successful in A 42-induced tau phosphorylation at concentrations considered safe for cell viability (serum starved SK-N-MC cells used). -SCBT Publication Review
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