Tropomyosin α Inhibitors
Tropomyosin α inhibitors are a specific class of chemical compounds that play a crucial role in the regulation of cellular processes related to muscle contraction and cytoskeletal organization. Tropomyosins are a family of proteins found in various cell types, with the α isoform being particularly prevalent in muscle tissues. These inhibitors are designed to interact with and modulate the activity of tropomyosin α, a protein that serves as a key component of the thin filament in muscle cells. The thin filament is a critical part of the contractile machinery in both skeletal and cardiac muscles, enabling the sliding of actin and myosin filaments during muscle contraction. Tropomyosin α, by binding along the actin filaments, helps regulate the exposure of myosin-binding sites on actin, thereby controlling the initiation and progress of muscle contraction.
Tropomyosin α inhibitors are primarily developed to influence the function of muscle cells and, consequently, have implications in various physiological processes beyond muscle contraction. By modulating tropomyosin α, these inhibitors can impact cell motility, cell shape, and cytoskeletal dynamics in non-muscle cells as well. This diverse set of cellular functions underscores the significance of tropomyosin α inhibitors in fundamental cellular processes and their applications in various research areas. Researchers and scientists studying muscle biology, cell motility, and cytoskeletal organization rely on these inhibitors as valuable tools to investigate the intricacies of cellular function and to better understand the roles of tropomyosin α in both muscle and non-muscle tissues.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor that induces DNA damage by stabilizing the topoisomerase-DNA complex, leading to single-strand breaks. This DNA damage could potentially impact transcription and expression of various genes, including Tropomyosin α. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
Alisertib is an Aurora kinase A inhibitor. By disrupting the function of this kinase, Alisertib can influence cell cycle progression and may impact the expression of certain genes, including Tropomyosin α. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin forms DNA adducts and induces DNA damage, which can disrupt transcription and potentially lead to altered gene expression, including reduced expression of Tropomyosin α. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate acts as a histone deacetylase inhibitor, altering chromatin structure and potentially modulating gene expression. This could lead to changes in the expression of Tropomyosin α. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Thalidomide modulates the expression of various genes through its effects on transcription factors and signaling pathways. This could potentially result in altered expression of Tropomyosin α. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, affecting DNA synthesis and potentially influencing gene expression, including that of Tropomyosin α. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can influence various signaling pathways, potentially leading to changes in gene expression, including Tropomyosin α. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor that can modulate signaling pathways involved in gene expression regulation, potentially affecting Tropomyosin α expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor that can influence protein synthesis and cell growth, potentially leading to altered expression of Tropomyosin α. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor that can affect various signaling pathways and potentially lead to changes in gene expression, including Tropomyosin α. | ||||||