Sodium Butyrate CAS: 156-54-7
MF: C4H7O2Na
MW: 110.09

Sodium Butyrate (CAS 156-54-7)

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Alternative Namen: Sodium Butyrate also known as Butyric acid sodium salt; Butanoicacidsodiumsalt butyratesodium; sodiumpropanecarboxylate
Anwendungen Sodium Butyrate is an HDAC inhibitor, apoptosis inducer and can induce differentiation and gene expression and also prevent cell proliferation
CAS Nummer: 156-54-7
Reinheit: ≥98%
Molekulargewicht: 110.09
Summenformel: C4H7O2Na
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
* Schauen Sie auf das Analysezertifikat (CoA), um die genauen Daten (inkl. Wassergehalt) Ihrer Produktionscharge (Lot) zu sehen.
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Sodium Butyrate has been reported to cause hyperacetylation of histones due to its role as a histone deacetylase (HDAC) inhibitor (IC50 values are 0.3, 0.4, 0.3, mM for HDAC1, 2 and 7 respectively). Sodium Butyrate has been shown to cause induction of differentiation and gene expression and also prevent cell proliferation. Mechanistic studies suggest that the action of Sodium Butyrate is often mediated through Sp1/Sp3-associated HDAC activity which leads to transcriptional activation of the p21 gene. Additionally Sodium Butyrate demonstrates the ability to downregulate numerous genes associated with cytokine signaling, specifically, the IFN-γ (interferon γ) pathway.


Literaturhinweise

1. Sealy, L., et al., 1978. The effect of sodium butyrate on histone modification. Cell. 14(1): 115-21. PMID: 667928

2. Davie, James R., et al., 2003. Inhibition of histone deacetylase activity by butyrate. The Journal of nutrition. 133(7 Suppl): 2485S-2493S. PMID: 12840228

3. Joseph, Jeena., et al., 2004. Expression profiling of sodium butyrate (NaB)-treated cells: identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB. Oncogene. 23(37): 6304-15. PMID: 15318170

4. Sekhavat, Anoushe., et al., 2007. Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate. Biochemistry and cell biology = Biochimie et biologie cellulaire. 85(6): 751-8. PMID: 18059533

Aggregatzustand :
Solid
Löslichkeit :
Soluble in water (0.1 g/ml), DMSO (<1 mg/ml), ethanol (~5 mg/ml), and PBS pH7.2 (~10 mg/ml). Insoluble in ether.
LAGERUNG: :
Store at -20° C
Schmelztemperatur :
250-253° C (lit.)
IC50 :
Histone deacetylase 7: IC50 = 140 µM (human); Histone deacetylase 8: IC50 = 140 µM (human); Histone deacetylase 1: IC50 = 140 µM (human)
Ki-Daten :
Carbonic anhydrase: Ki= 26.9 µM (Candida albicans ); Carbonic anhydrase I: Ki= 511 µM (human)
pK Werte :
pKa: 4.82
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
Deutsche WGK :
1
RTECS :
ET6400000
PubChem CID :
MDL-Nummer :
MFCD00002816
EC-Nummer :
205-857-6
Beilstein-Registernummer :
3629439
SMILES :
CCCC(=O)[O-].[Na+]

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Analysenzertifikat

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Sodium Butyrate (CAS 156-54-7)  Publikationen

Lesen Sie wie andere Anwender Sodium Butyrate (CAS 156-54-7) eingesetzt haben. Klicken Sie auf den jeweiligen Eintrag um den entsprechenden PubMed-Abstract abzurufen .

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PMID: # 29235036  Ho, CF.|Bon, CP.|Ng, YK.|Herr, DR.|Wu, JS.|Lin, TN.|Ong, WY.| et al. 2018. Neurochem. Res. 43: 540-555.

PMID: # 25342559  Yang, Y. et al. 2014. Cell Res. 24: 1342-53.

PMID: # 24682235  Simiczyjew, A.|Mazur, AJ.|Popow-Woźniak, A.|Malicka-Błaszkiewicz, M.|Nowak, D.| et al. 2014. Histochem Cell Biol. 142: 307-22.

PMID: # 17967882  Pesavento, JJ. et al. 2008. Mol. Cell. Biol. 28: 468-486.

PMID: # 17881451  Neumann, DM. et al. 2007. J. Virol. 81: 13248-13253.

PMID: # 16699007  Lu, F. et al. 2006. J. Virol. 80: 5273-5282.

PMID: # 12654818  Scaife, H. et al. 2003. Infect. Immun. 71: 1995-2001.

PMID: # 11884567  Chiou, CJ. et al. 2002. J. Virol. 76: 3421-3439.

PMID: # 10639456  Gerçeker, AA. et al. 2000. Infect. Immun. 68: 861-870.

PMID: # 9971760  Gasmi, M. et al. 1999. J. Virol. 73: 1828-1834.

Produktreferenz 1 bis 10 von 13 insgesamt
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