TRAP-δ activators belong to a class of chemical compounds designed to modulate the activity of the TRAP-δ protein. TRAP-δ, also known as the tartrate-resistant acid phosphatase type 5 (ACP5), is an enzyme found in cells and tissues such as osteoclasts, where it plays a role in bone metabolism. TRAP-δ is part of the acid phosphatase family, and it is involved in the regulation of phosphate metabolism and bone resorption. These activators are designed to interact with TRAP-δ, potentially enhancing or regulating its enzymatic activity.
The primary function of TRAP-δ activators is to influence the activity of this enzyme, which is crucial in the process of bone remodeling. In particular, TRAP-δ is known for its role in osteoclast function, where it helps break down bone tissue by degrading phosphate compounds. This process is essential for maintaining bone health and homeostasis, as it allows the body to remove old or damaged bone tissue and replace it with new bone. Research into TRAP-δ activators contributes to our understanding of bone metabolism and the molecular mechanisms involved in bone resorption. These activators may hold potential implications for the development of interventions aimed at modulating bone remodeling processes in various contexts, from bone diseases to bone health maintenance. Further studies are needed to elucidate the precise mechanisms of action and the broader biological consequences associated with TRAP-δ activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, which can induce the unfolded protein response, potentially upregulating SSR4 as part of the adaptive response. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
As an ER stress inducer, thapsigargin may trigger an upregulation of SSR4 expression due to increased protein translocation demand. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
This compound disrupts ER to Golgi transport, which could lead to compensatory responses including the upregulation of SSR4. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $75.00 $163.00 $622.00 $4906.00 $32140.00 | 43 | |
This chemical chaperone can reduce ER stress, potentially modulating the expression of SSR4 in the process. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
As a proteasome inhibitor, MG132 can lead to ER stress and may increase the expression of SSR4 to handle misfolded proteins. | ||||||
β-Mercaptoethanol | 60-24-2 | sc-202966A sc-202966 | 100 ml 250 ml | $88.00 $118.00 | 10 | |
By disrupting disulfide bond formation, it can cause protein misfolding and ER stress, potentially upregulating SSR4. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine accumulates in the ER, which could induce stress and upregulate SSR4 as a compensatory mechanism. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to affect the ER stress pathway, which might influence SSR4 expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
As a histone deacetylase inhibitor, sodium butyrate can affect gene expression, potentially including that of SSR4. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
This immunosuppressant can inhibit calcineurin, affecting cellular stress responses and potentially SSR4 expression. | ||||||