TRAP-δ Inhibitors
TRAP-δ inhibitors, belonging to a specialized class of chemical compounds, are a group of molecules designed to selectively target and modulate the activity of the protein known as TRAP-δ, or Translocon-Associated Protein Delta. TRAP-δ is a crucial component of the cellular machinery responsible for protein translocation across the endoplasmic reticulum (ER) membrane in eukaryotic cells. This process, referred to as co-translational translocation, plays an integral role in the biogenesis of secretory and membrane proteins, ensuring their proper folding, assembly, and insertion into the ER membrane. TRAP-δ, as an essential subunit of the translocon complex, interacts with nascent polypeptide chains emerging from ribosomes and assists in their translocation into the ER lumen. TRAP-δ inhibitors are designed to interfere with this intricate molecular process, modulating protein translocation with potential applications in basic research and pharmacology.
The development of TRAP-δ inhibitors involves the design and synthesis of small molecules or peptides that can specifically interact with TRAP-δ, disrupting its function. By inhibiting TRAP-δ activity, these compounds have the potential to influence the translocation of specific proteins, thereby impacting various cellular processes and potentially serving as valuable tools for studying protein targeting and membrane protein biogenesis. Researchers in cell biology and molecular biology utilize TRAP-δ inhibitors to investigate the underlying mechanisms of protein translocation and its significance in cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Efonidipine hydrochloride | 111011-53-1 | sc-294464 sc-294464A | 10 mg 50 mg | $102.00 $408.00 | ||
Efonidipine is a dihydropyridine calcium channel blocker that selectively inhibits L-type calcium channels in smooth muscle cells. By blocking calcium influx, it reduces smooth muscle contraction, leading to vasodilation and lower blood pressure. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a phenylalkylamine calcium channel blocker that inhibits L-type calcium channels in cardiac and smooth muscle cells. It decreases calcium entry into cells, reducing contractility and heart rate. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $73.00 $163.00 | 2 | |
Amlodipine is another dihydropyridine calcium channel blocker that selectively inhibits L-type calcium channels in vascular smooth muscle cells, promoting vasodilation and lowering blood pressure. | ||||||
Felodipine | 72509-76-3 | sc-201483 sc-201483A | 10 mg 50 mg | $89.00 $218.00 | 1 | |
Felodipine is a dihydropyridine calcium channel blocker that selectively inhibits L-type calcium channels in vascular smooth muscle cells, leading to vasodilation and blood pressure reduction. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine, a dihydropyridine calcium channel blocker, selectively inhibits L-type calcium channels in smooth muscle cells. This action relaxes vascular smooth muscle, lowering blood pressure. | ||||||
Nimodipine | 66085-59-4 | sc-201464 sc-201464A | 100 mg 1 g | $60.00 $301.00 | 2 | |
Nimodipine is a dihydropyridine calcium channel blocker that specifically inhibits L-type calcium channels in cerebral blood vessels. It helps prevent vasospasm and improve cerebral blood flow after subarachnoid hemorrhage. | ||||||
Nicardipine hydrochloride | 54527-84-3 | sc-202731 sc-202731A | 1 g 5 g | $32.00 $81.00 | 5 | |
Nicardipine, a dihydropyridine calcium channel blocker, selectively inhibits L-type calcium channels in vascular smooth muscle cells, leading to vasodilation and decreased blood pressure. | ||||||
Isradipine | 75695-93-1 | sc-201467 sc-201467A | 10 mg 50 mg | $86.00 $318.00 | 1 | |
Isradipine is a dihydropyridine calcium channel blocker that selectively inhibits L-type calcium channels in smooth muscle cells. This leads to vasodilation and reduced blood pressure. | ||||||
trans Lacidipine | 103890-78-4 | sc-213066 | 10 mg | $153.00 | ||
Lacidipine, a dihydropyridine calcium channel blocker, selectively inhibits L-type calcium channels in vascular smooth muscle, promoting vasodilation and reducing blood pressure. | ||||||