Molecular structure of trans Lacidipine, CAS Number: 103890-78-4
trans Lacidipine (CAS 103890-78-4)
Application:
trans Lacidipine is a calcium channel protein inhibitor and blocker
CAS Number:
103890-78-4
Purity:
≥98%
Molecular Weight:
455.54
Molecular Formula:
C26H33NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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trans Lacidipine is a dihydropyridine calcium channel protein inhibitor and blocker. Structurally, trans Lacidipine is characterized by its cinnamate moiety, which results in specific photochemical properties that differ from other dihydropyridine. Studies indicate that upon irradtiation with monochromatic radiation at λ=313 nm, cis Lacidipine (sc-217905) was degraded and the concentration of trans Lacidipine was increased. It is known that calcium channel blockers such as trans Lacidipine function by blocking voltage gated calcium channels on cell membranes of cardiac muscle and blood vessels. As a result of this inhibition there is a reduction in cardiac muscle and blood vessel contraction.
trans Lacidipine (CAS 103890-78-4) References
- Photodegradation studies on lacidipine in solution: basic experiments with a cis-trans reversible photoequilibrium under UV-A radiation exposure. | De Filippis, P., et al. 2002. J Pharm Biomed Anal. 27: 803-12. PMID: 11814721
- Instability of calcium channel antagonists during sample preparation for LC-MS-MS analysis of serum samples. | Baranda, AB., et al. 2006. Forensic Sci Int. 156: 23-34. PMID: 16410150
- Interaction between dihydropyridines and phospholipid bilayers: a molecular dynamics simulation. | Aiello, M., et al. 1998. Eur Biophys J. 27: 211-8. PMID: 9615394
Inhibitor of:
CA XI, CaBP2, Cacna2d1, Cacna2d2, Cacna2d3, Cacna2d4, Calcium Channel Protein, CAMTA1, CAPS-2, CLCA2_Clac2, L-type Ca++ CP α1C, L-type Ca++ CP α1F, L-type Ca++ CP β1, L-type Ca++ CP β4, L-type Ca++ CP γ1, L-type Ca++ CP γ2, L-type Ca++ CP γ4, L-type Ca++ CP γ5, L-type Ca++ CP γ6, L-type Ca++ CP γ8, L-type calcium channel α1C, L-type calcium channel α1D, L-type calcium channel α1F, L-type calcium channel β1, L-type Calcium Channel γ, Olfr769, Olr401, Olr409, Olr418, Raftlin, TRAP-δ, and Troponin C slow skeletal.Activator of:
L-type Ca++ CP γ4, L-type Ca++ CP γ5, L-type Ca++ CP γ7, L-type calcium channel α1C, and NCKX1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
trans Lacidipine, 10 mg | sc-213066 | 10 mg | $153.00 |