Molecular structure of Amlodipine, CAS Number: 88150-42-9
Amlodipine (CAS 88150-42-9)
See product citations (2)
Application:
Amlodipine is an L-type calcium channel protein inhibitor and blocker
CAS Number:
88150-42-9
Purity:
>98%
Molecular Weight:
408.88
Molecular Formula:
C20H25ClN2O5
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Amlodipine is a notable calcium channel blocker primarily used in research applications to study its vasodilating effects through the inhibition of calcium influx in vascular smooth muscle cells. By selectively targeting L-type calcium channels, amlodipine stabilizes the influx of calcium ions, which is a critical component for muscle contraction processes within these cells. This mechanism is particularly useful in exploring the regulation of blood vessel diameter under various experimental conditions. Moreover, Amlodipine inhibits growth of human epidermoid carcinoma A431 cells. The extended duration of effect allows researchers to investigate the sustained impacts of altered calcium channel activity on vascular function, providing insights into the cellular responses that underpin vasodilation and their potential modulation in vascular-related pathologies.
Amlodipine (CAS 88150-42-9) References
- The influence of nimodipine, nicardipine and amlodipine on the brain free fatty acid level in rats with penicillin-induced seizures. | Zupan, G., et al. 1999. Prog Neuropsychopharmacol Biol Psychiatry. 23: 951-61. PMID: 10509387
- Antiproliferative effect of Ca2+ channel blockers on human epidermoid carcinoma A431 cells. | Yoshida, J., et al. 2003. Eur J Pharmacol. 472: 23-31. PMID: 12860469
- Amlodipine modulates THP-1 cell adhesion to vascular endothelium via inhibition of protein kinase C signal transduction. | Yu, T., et al. 2003. Hypertension. 42: 329-34. PMID: 12900427
- A comparative assessment of the duration of action of amlodipine and nifedipine GITS in normotensive subjects. | Ueda, S., et al. 1993. Br J Clin Pharmacol. 36: 561-6. PMID: 12959273
- Novel vascular biology of third-generation L-type calcium channel antagonists: ancillary actions of amlodipine. | Mason, RP., et al. 2003. Arterioscler Thromb Vasc Biol. 23: 2155-63. PMID: 14512371
- A calcium channel blocker activates both ecto-5(')-nucleotidase and NO synthase in HUVEC. | Asano, Y., et al. 2003. Biochem Biophys Res Commun. 311: 625-8. PMID: 14623316
- Inhibition of oxidative stress and improvement of endothelial function by amlodipine in angiotensin II-infused rats. | Zhou, MS., et al. 2004. Am J Hypertens. 17: 167-71. PMID: 14751660
- Asymmetric dimethylarginine in end-stage renal disease patients: a biomarker modifiable by calcium blockade and angiotensin II antagonism? | Zoccali, C. 2006. Kidney Int. 70: 2053-5. PMID: 17136131
- Liquid chromatography-mass spectrometry method for the determination of amlodipine in human plasma and its application in a bioequivalence study. | Zou, Q., et al. 2009. Arzneimittelforschung. 59: 383-91. PMID: 19813460
- Effects of dihydropyridine calcium channel blockers on oxidized low-density lipoprotein induced proliferation and oxidative stress of vascular smooth muscle cells. | Zou, J., et al. 2012. BMC Res Notes. 5: 168. PMID: 22455621
- TRPC1, CaN and NFATC3 signaling pathway in the pathogenesis and progression of left ventricular hypertrophy in spontaneously hypertensive rats. | Zou, G., et al. 2015. Clin Exp Hypertens. 37: 223-34. PMID: 25271479
- Effects of Amlodipine on Bone Metabolism in Orchidectomised Spontaneously Hypertensive Rats. | Zivna, H., et al. 2018. Pharmacology. 102: 67-73. PMID: 29898457
- Effects of nimodipine, felodipine and amlodipine on electroconvulsive shock-induced amnesia in the rat. | Zupan, G., et al. 1996. Eur J Pharmacol. 310: 103-6. PMID: 8884204
Inhibitor of:
αENaC, 2610021K21Rik, 4930408G06Rik, 4931407G18Rik, BRSK1, C17orf57, C2orf48, C3orf25, CA II, CA XI, CAB39L, CaBP2, CaBP4, CaBP8, Cacna2d1, Cacna2d2, Cacna2d3, Cacna2d4, Calcium Channel Protein, CALR3, calsequestrin 1, calsequestrin 2, CaMKIγ, CAMTA1, CAPS-2, CCDC109B, CCDC90A, Chr-A, CLCA2_Clac2, cyclin M3, Cyp3a18, DJBP, Dystrophin-Glycoprotein Complex (DGC; Sarcospan), EBPL, Gm13247, Grancalcin, IQCC, Junctophilin-2, kallistatin, L-Selectin, L-type Ca++ CP α1C, L-type Ca++ CP α1C/1D/1F/1S, L-type Ca++ CP α1S, L-type Ca++ CP β1, L-type Ca++ CP β4, L-type Ca++ CP γ1, L-type Ca++ CP γ2, L-type Ca++ CP γ4, L-type Ca++ CP γ5, L-type Ca++ CP γ6, L-type Ca++ CP γ7, L-type Ca++ CP γ8, L-type calcium channel α1C, L-type calcium channel α1D, L-type calcium channel α1F, L-type calcium channel β1, L-type Calcium Channel γ, LPAAT-δ, LYCAT, Mg29, Mitsugumin23, MYH11, Myozenin (MYOZ), N-type calcium channel α1B, NCKX2, neurocalcin, NKCC1, nucleobindin, Olfr1100, Olfr352, Olfr509, Olfr728, Olfr740, Olfr741, Olfr742, Olfr744, Olfr745, Olfr746, Olfr769, Olfr822, Olfr824, Olfr955, Olfr959, Olr1511, Olr1514, Olr211, Olr222, Olr251, Olr27, Olr413, Olr420, Olr434, OR4D9, OR4K15, PBR, PMCA3, PMR1, PP2B-Aα, Raftlin, Relaxin 1, ROG, S-100A3, S-100P, SCRN1, SHISA4, SMPDL3B, SUR1, T-type Ca++ CP α1G, TMCO1, TMEM63A, TMEM66, TRAP-δ, Troponin C, Troponin C slow skeletal, Troponin T, Troponin T-FS, Unc79, Vasculin, Vmn2r76, and WNK3.Activator of:
3β-HSD2, ABCA14, AGTRAP, Alpha 4, ATP11B, BBOX1, Cacna2d1, Cacna2d4, CALM, calsequestrin 2, Calumenin, CD81, CHP2, CYP2J9, DREAM, DSCR 1, EF-CAB2, ET-3, GAIP, GATA-5, GCAP2, GRK 3, KCNMB3, KIAA0649, L-type Ca++ CP α1F, L-type Ca++ CP β2, L-type Ca++ CP γ2, L-type Ca++ CP γ4, L-type Ca++ CP γ5, L-type Ca++ CP γ7, L-type calcium channel α1C, L-type calcium channel α1D, MKP-4, N-type Ca CP α1B, Na+ CP type Iα, Na+ CP type IIIβ, NALCN, NCKX1, NCKX5, NCKX6, NCX1, NMUR1, Popeye 3, PP2B-Aγ, PRODH2, R-type calcium channel α1E, Recoverin, SLC12A8, SREBP-2, striatin, T-type Ca++ CP α1I, TMEM164, TMEM35, Triadin, V3R 11, Varicella Zoster Virus IE62, VILIP-2, and Vmn1r125.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Amlodipine, 100 mg | sc-200195 | 100 mg | $74.00 | |||
Amlodipine, 1 g | sc-200195A | 1 g | $166.00 | |||
| US: (Out of Stock: Availability February 16, 2026) | ||||||