TRAP-δ Antibody (C-6): sc-376706
- TRAP-δ Antibody (C-6) is a mouse monoclonal IgG1 κ TRAP-δ antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-173 representing full length TRAP-δ of human origin
- TRAP-delta Antibody (C-6) is recommended for detection of TRAP-δ of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-TRAP-delta Antibody (C-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TRAP-δ Antibody (C-6) for WB and IHC(P) applications. These reagents are now offered in bundles with TRAP-δ Antibody (C-6) (see ordering information below).
TRAP-δ Antibody (C-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects TRAP-delta protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TRAP-δ (C-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TRAP-delta is a crucial component of the translocon-associated protein complex, which plays a significant role in the endoplasmic reticulum (ER) by facilitating the translocation of nascent polypeptides into the ER lumen. This process is vital for proper protein folding and maturation, as well as for maintaining cellular homeostasis. The TRAP complex, which includes TRAP-α, TRAP-β, TRAP-γ, and TRAP-δ, interacts with the Sec61 translocon, the primary machinery responsible for protein translocation across the ER membrane. TRAP-delta is involved in the ER-associated degradation pathway, which is essential for the removal of misfolded proteins, thereby preventing the accumulation of potentially toxic aggregates. TRAP-delta and associated proteins are upregulated through the XBP-1/IRE1α signaling pathway during ER stress, highlighting their role in cellular stress responses.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TRAP-δ Antibody (C-6) References:
- Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum. | Wang, L. and Dobberstein, B. 1999. FEBS Lett. 457: 316-22. PMID: 10471800
- The Translocon-Associated Protein beta (TRAPbeta) in zebrafish embryogenesis. I. Enhanced expression of transcripts in notochord and hatching gland precursors. | Mangos, S., et al. 2000. Mol Cell Biochem. 215: 93-101. PMID: 11204460
- Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane. | Fons, RD., et al. 2003. J Cell Biol. 160: 529-39. PMID: 12578908
- Cloning and molecular characterization of a human ortholog of Monodelphis TRAPD in ultraviolet B-induced melanoma. | Wang, Z. and VandeBerg, JL. 2004. Melanoma Res. 14: 107-14. PMID: 15057039
- Architecture of the ribosome-channel complex derived from native membranes. | Ménétret, JF., et al. 2005. J Mol Biol. 348: 445-57. PMID: 15811380
- Mutation in the Trapalpha/Ssr1 gene, encoding translocon-associated protein alpha, results in outflow tract morphogenetic defects. | Mesbah, K., et al. 2006. Mol Cell Biol. 26: 7760-71. PMID: 17015483
- Simultaneous induction of the four subunits of the TRAP complex by ER stress accelerates ER degradation. | Nagasawa, K., et al. 2007. EMBO Rep. 8: 483-9. PMID: 17380188
- A tetrameric complex of membrane proteins in the endoplasmic reticulum. | Hartmann, E., et al. 1993. Eur J Biochem. 214: 375-81. PMID: 7916687
- Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. | Brenner, V., et al. 1997. Genomics. 44: 8-14. PMID: 9286695
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRAP-δ Antibody (C-6) | sc-376706 | 200 µg/ml | $322.00 | |||
TRAP-δ Antibody (C-6): m-IgG Fc BP-HRP Bundle | sc-529925 | 200 µg Ab; 10 µg BP | $361.00 | |||
TRAP-δ Antibody (C-6): m-IgGκ BP-HRP Bundle | sc-523053 | 200 µg Ab, 40 µg BP | $361.00 | |||
TRAP-δ Antibody (C-6): m-IgG1 BP-HRP Bundle | sc-543769 | 200 µg Ab; 20 µg BP | $361.00 | |||
TRAP-δ Antibody (C-6) AC | sc-376706 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TRAP-δ Antibody (C-6) HRP | sc-376706 HRP | 200 µg/ml | $322.00 | |||
TRAP-δ Antibody (C-6) FITC | sc-376706 FITC | 200 µg/ml | $336.00 | |||
TRAP-δ Antibody (C-6) PE | sc-376706 PE | 200 µg/ml | $349.00 | |||
TRAP-δ Antibody (C-6) Alexa Fluor® 488 | sc-376706 AF488 | 200 µg/ml | $364.00 | |||
TRAP-δ Antibody (C-6) Alexa Fluor® 546 | sc-376706 AF546 | 200 µg/ml | $364.00 | |||
TRAP-δ Antibody (C-6) Alexa Fluor® 594 | sc-376706 AF594 | 200 µg/ml | $364.00 | |||
TRAP-δ Antibody (C-6) Alexa Fluor® 647 | sc-376706 AF647 | 200 µg/ml | $364.00 | |||
TRAP-δ Antibody (C-6) Alexa Fluor® 680 | sc-376706 AF680 | 200 µg/ml | $364.00 | |||
TRAP-δ Antibody (C-6) Alexa Fluor® 790 | sc-376706 AF790 | 200 µg/ml | $364.00 |