Trak1 Inhibitors
Chemical inhibitors of Trak1 can interfere with its function by modulating various signaling pathways and molecular interactions that are crucial for its role in cellular processes. For instance, 1,9-Pyrazoloanthrone and SP600125, both JNK inhibitors, can inhibit the JNK pathway that influences Trak1 activity, particularly in the context of mitochondrial dynamics within neuronal cells. Similarly, Bisindolylmaleimide I, which selectively targets Protein Kinase C (PKC), can alter Trak1 functionality by inhibiting PKC-dependent phosphorylation processes that Trak1 is a part of. W-7 Hydrochloride, by inhibiting Calmodulin, can affect the activity of Calmodulin-dependent kinases that phosphorylate Trak1, thereby potentially reducing Trak1's role in intracellular signaling.
Additionally, Genistein, acting as a tyrosine kinase inhibitor, can reduce tyrosine phosphorylation of Trak1, a post-translational modification that typically regulates the protein's activity. LY294002 and Wortmannin, both inhibitors of PI3K, can suppress Trak1-mediated pathways, particularly those related to neuronal survival and axonal growth. SB203580 and U0126, which inhibit p38 MAPK and MEK1/2 respectively, can attenuate Trak1's involvement in cellular stress response pathways regulated by the MAPK/ERK cascade. Y-27632, as a ROCK inhibitor, can affect Trak1's influence on cytoskeletal dynamics due to its role in regulating the assembly and disassembly of cytoskeletal structures. Finally, PP2, an inhibitor of Src family kinases, can prevent the phosphorylation of Trak1 by Src kinases, which is an important mechanism for the activation and function of Trak1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
This chemical is a known JNK inhibitor. JNK pathway can influence the function of Trak1, particularly in neuronal cells where Trak1 is involved in mitochondrial trafficking. By inhibiting JNK, 1,9-Pyrazoloanthrone may reduce Trak1-mediated mitochondrial movement. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a potent and selective inhibitor of Protein Kinase C (PKC). Trak1 is known to interact with PKC-dependent signaling pathways, and inhibition of PKC can result in reduced phosphorylation and activity of Trak1. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
This chemical inhibits Calmodulin, which interacts with various kinases that can phosphorylate Trak1. W-7 Hydrochloride's inhibition of Calmodulin-dependent kinases may decrease Trak1 phosphorylation and its associated activities. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. Since Trak1's function is modulated by tyrosine phosphorylation, Genistein's inhibitory effect on tyrosine kinases can diminish the phosphorylation and subsequent activity of Trak1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K signaling can regulate Trak1 activity, particularly in neuronal survival and axonal outgrowth. Inhibition of PI3K can lead to reduced activity of Trak1 in these pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. Trak1 is implicated in MAPK signaling related to cellular stress responses. Inhibition of p38 MAPK can reduce Trak1's participation in these stress response pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which is upstream of ERK in the MAPK pathway. Since Trak1 can be regulated by the MAPK pathway, inhibition of MEK by PD98059 would result in reduced Trak1 activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor. Trak1 is involved in cytoskeletal dynamics, and ROCK signaling affects this process. By inhibiting ROCK, Y-27632 may reduce Trak1's role in cytoskeletal organization. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an Src family kinase inhibitor. Src kinases can phosphorylate Trak1, an important step for its activation. PP2, therefore, can inhibit Trak1 activity by preventing its phosphorylation by Src kinases. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor with a mechanism similar to LY294002. It inhibits PI3K, impacting pathways in which Trak1 is involved, leading to a reduction in Trak1 activity. | ||||||