TMEM62 Activators
TMEM62 Activators are a group of chemical compounds that indirectly enhance the functional activity of TMEM62 through various signaling pathways associated with autophagy. Compounds such as Forskolin, Ionomycin, and A23187 elevate intracellular levels of cAMP and calcium respectively, which can activate PKA and calcium-dependent kinases; these kinases can phosphorylate proteins within the autophagy pathway, thus potentially enhancing TMEM62's role in autophagosome formation. Rapamycin, as an mTOR inhibitor, directly initiates autophagy by deactivating a major negative regulator of this process, which could consequently lead to increased TMEM62 activity as it is involved in autophagy regulation. Similarly, Urolithin A and Spermidine, by inducing mitophagy and autophagy, respectively, may augment the functional activity of TMEM62 in the clearance of damaged organelles and the general autophagic process.
Furthermore, Resveratrol, through the activation of SIRT1, and Salicylate, by activating AMPK, enhance autophagy, which is likely to indirectly augment TMEM62's function in this pathway. Lithium and Metformin both act through inhibitory mechanisms on inositol monophosphatase and mTOR signaling respectively, thereby inducing autophagy, which in turn could enhance the activity of TMEM62. Nicotinamide, by inhibiting sirtuins and thereby activating autophagy, and Trehalose, through its direct induction of autophagy, represent additional compounds that can potentially amplify the functional activity of TMEM62 related to autophagic processes. The cumulative effect of these activators, by targeting distinct but converging pathways, supports the enhancement of TMEM62's role in autophagy, an essential cellular mechanism for maintaining homeostasis and responding to stress.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is known to activate adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP can enhance the functional activity of TMEM62 by promoting cAMP-dependent protein kinase (PKA) signaling, which may phosphorylate and activate proteins in the autophagy pathway where TMEM62 is a key component. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, thereby potentially activating calcium-dependent protein kinases. This increase in calcium signaling could enhance the function of TMEM62 by modulating its role in autophagosome formation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187, another calcium ionophore, similarly to Ionomycin, can increase intracellular calcium and thus stimulate calcium-dependent signaling pathways that could indirectly enhance the activity of TMEM62 by influencing autophagosome maturation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor that initiates autophagy by inhibiting the mTOR pathway. As TMEM62 is implicated in the regulation of autophagy, the inhibition of mTOR by Rapamycin could indirectly enhance the functional activity of TMEM62. | ||||||
Urolithin A | 1143-70-0 | sc-475514 sc-475514A sc-475514B sc-475514C | 25 mg 100 mg 1 g 5 g | $204.00 $459.00 $714.00 $1224.00 | 10 | |
Urolithin A is known to induce mitophagy, a selective form of autophagy. It can enhance the functional activity of TMEM62 by promoting the clearance of damaged mitochondria, a process in which TMEM62 may be involved. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine is a natural polyamine that can induce autophagy. By stimulating autophagy, Spermidine may enhance the functional activity of TMEM62 in the autophagic process. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates sirtuin 1 (SIRT1), and SIRT1 activation enhances autophagy. Since TMEM62 is involved in autophagy, Resveratrol may indirectly enhance TMEM62's activity by promoting autophagic flux. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium is known to inhibit inositol monophosphatase, leading to the depletion of inositol and the inhibition of the phosphoinositide signaling pathway, which may result in the enhancement of autophagy and subsequent activation of TMEM62. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin activates AMP-activated protein kinase (AMPK), which in turn can inhibit mTOR signaling, leading to the induction of autophagy. Through this pathway, Metformin may enhance the functional activity of TMEM62. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide inhibits sirtuins, including SIRT1, leading to the activation of autophagy. This indirect mechanism could enhance the functional activity of TMEM62 by promoting autophagic processes. | ||||||