Molecular structure of Urolithin A, CAS Number: 1143-70-0
Urolithin A (CAS 1143-70-0)
See product citations (10)
Alternate Names:
3,8-Hydroxydibenzo-α-pyrone; 3,8-Dihydroxyurolithin
Application:
Urolithin A is a metabolite of ellagitannin
CAS Number:
1143-70-0
Purity:
≥94%
Molecular Weight:
228.20
Molecular Formula:
C13H8O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Urolithin A is extensively studied in the context of cellular metabolism and its effects on oxidative stress and inflammation. In research models, Urolithin A is used to investigate signaling pathways that may influence longevity and cellular health. It is also of interest in the study of autophagy, a cellular recycling process, as Urolithin A may act to induce autophagy in certain experimental setups. Environmental scientists are interested in Urolithin A for its occurrence and stability in natural ecosystems, as it can result from the metabolic processes of local fauna or from human activity. The compound is a key tool in advancing knowledge in fields such as biochemistry and environmental science.
Urolithin A (CAS 1143-70-0) References
- Urolithin A, C, and D, but not iso-urolithin A and urolithin B, attenuate triglyceride accumulation in human cultures of adipocytes and hepatocytes. | Kang, I., et al. 2016. Mol Nutr Food Res. 60: 1129-38. PMID: 26872561
- Pomegranate polyphenols and urolithin A inhibit α-glucosidase, dipeptidyl peptidase-4, lipase, triglyceride accumulation and adipogenesis related genes in 3T3-L1 adipocyte-like cells. | Les, F., et al. 2018. J Ethnopharmacol. 220: 67-74. PMID: 29604377
- Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice. | Gong, Z., et al. 2019. J Neuroinflammation. 16: 62. PMID: 30871577
- Gut Bacterial Metabolite Urolithin A (UA) Mitigates Ca2+ Entry in T Cells by Regulating miR-10a-5p. | Zhang, S., et al. 2019. Front Immunol. 10: 1737. PMID: 31417547
- Urolithin A targets the PI3K/Akt/NF-κB pathways and prevents IL-1β-induced inflammatory response in human osteoarthritis: in vitro and in vivo studies. | Fu, X., et al. 2019. Food Funct. 10: 6135-6146. PMID: 31497826
- Pancreas protective effects of Urolithin A on type 2 diabetic mice induced by high fat and streptozotocin via regulating autophagy and AKT/mTOR signaling pathway. | Tuohetaerbaike, B., et al. 2020. J Ethnopharmacol. 250: 112479. PMID: 31846746
- Urolithin A-induced mitophagy suppresses apoptosis and attenuates intervertebral disc degeneration via the AMPK signaling pathway. | Lin, J., et al. 2020. Free Radic Biol Med. 150: 109-119. PMID: 32105828
- Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes. | Ding, SL., et al. 2020. J Inflamm (Lond). 17: 13. PMID: 32210738
- Lythrum salicaria L. herb and gut microbiota of healthy post-weaning piglets. Focus on prebiotic properties and formation of postbiotic metabolites in ex vivo cultures. | Dadi, TH., et al. 2020. J Ethnopharmacol. 261: 113073. PMID: 32673710
- Recommendations for standardizing nomenclature for dietary (poly)phenol catabolites. | Kay, CD., et al. 2020. Am J Clin Nutr. 112: 1051-1068. PMID: 32936878
- Metabolites of the ellagitannin, geraniin inhibit human ACE; in vitro and in silico evidence. | Looi, D., et al. 2021. Int J Food Sci Nutr. 72: 470-477. PMID: 33032478
- Urolithin A ameliorates experimental autoimmune encephalomyelitis by targeting aryl hydrocarbon receptor. | Shen, PX., et al. 2021. EBioMedicine. 64: 103227. PMID: 33530002
- The gut microbiota metabolite urolithin A inhibits NF-κB activation in LPS stimulated BMDMs. | Abdelazeem, KNM., et al. 2021. Sci Rep. 11: 7117. PMID: 33782464
- Urolithin a alleviates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells through SIRT1/PGC-1α pathway. | Shi, PZ., et al. 2021. World J Stem Cells. 13: 1928-1946. PMID: 35069991
- The potential antidiabetic properties of green and purple tea [Camellia sinensis (L.) O Kuntze], purple tea ellagitannins, and urolithins. | Tolmie, M., et al. 2023. J Ethnopharmacol. 309: 116377. PMID: 36907477
Inhibitor of:
MUL1.Activator of:
ALG-2, ATAD1, ATAD3B, ATP11, Bcl-rambo, CHCHD3, CHMP4A, Desmuslin, dystrotelin, GβL, GSTA3, HEI10, LYRM9, mKIAA1530, MRP-L14, MRP-L27, MRP-L46, MSK2, Mtch2, MTP18, Myotilin, OPA1, Paraplegin, RARS2, RPAIN, SLC25A36, SMCR7, Sp110, STK32C, TCP-1 η, TMEM62, Trap1a, Vps34, WBP2, and Ypk1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Urolithin A, 25 mg | sc-475514 | 25 mg | $204.00 | |||
Urolithin A, 100 mg | sc-475514A | 100 mg | $459.00 | |||
Urolithin A, 1 g | sc-475514B | 1 g | $714.00 | |||
Urolithin A, 5 g | sc-475514C | 5 g | $1224.00 |