TMEM215 Activators
TMEM215, denoting a "transmembrane protein 215," could be a protein embedded in the lipid bilayer of cells, participating in a variety of cellular functions such as signaling, ion transport, or acting as a receptor for specific molecules. Activators targeting a protein like TMEM215 would typically be designed to enhance its function, which could involve increasing protein stability, facilitating its proper localization within the cell, or promoting its interaction with other cellular components. These activators could function by binding directly to TMEM215, altering its conformation to a more active state, or by modulating the cellular environment to favor the protein's activity.
The development of a class of TMEM215 activators would require detailed knowledge of the protein's structure and function. If TMEM215 were part of a cellular pathway or process, scientists would first aim to understand the exact role of the protein within that context. Structural studies, such as X-ray crystallography or cryo-electron microscopy, would be employed to ascertain the three-dimensional conformation of TMEM215, identifying potential binding sites for activators. Once these sites are identified, a combination of chemical synthesis and high-throughput screening could be used to generate and identify molecules capable of binding to TMEM215 and increasing its activity. These molecules would then undergo a series of optimization processes, including structure-activity relationship (SAR) studies, to refine their potency, selectivity, and stability. The goal of such research would be to produce compounds that can reliably interact with TMEM215 and modulate its activity in a controlled and specific manner, contributing to a fundamental understanding of the protein's role within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing cAMP levels in the cell. Elevated cAMP activates PKA, which could phosphorylate and alter the function or localization of TMEM215, thus enhancing its activity within its specific cellular context. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which prevents cAMP degradation. This leads to increased cAMP levels, indirectly enhancing the activity of cAMP-dependent pathways and possibly increasing the functional activity of TMEM215 through similar mechanisms as Forskolin. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration. Elevated calcium levels can activate calcium-dependent signaling cascades that may indirectly enhance the functional activity of TMEM215 through calcium-sensitive pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in various signaling pathways. PKC activation could lead to phosphorylation events that enhance the activity or localization of TMEM215 within specific signaling pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 acts as another calcium ionophore, similarly to Ionomycin, increasing intracellular calcium levels and potentially enhancing the activity of TMEM215 through calcium-dependent signaling mechanisms. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P is a bioactive lipid that activates S1P receptors, triggering downstream signaling pathways that could lead to the enhancement of TMEM215's activity by influencing its localization or function in the context of lipid signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can alter PI3K/Akt signaling pathways. By inhibiting this pathway, there could be a compensatory enhancement in alternate pathways where TMEM215 is involved, potentially leading to its increased activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that can alter gene expression patterns. While not directly activating TMEM215, it could lead to changes in the cellular environment that increase TMEM215 activity due to epigenetic modifications of genes in relevant signaling pathways. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
Zaprinast inhibits PDE5, leading to increased cGMP levels which can activate PKG. Activation of PKG signaling pathways could indirectly enhance the activity of TMEM215 by altering the phosphorylation status of proteins in pathways where TMEM215 is functionally active. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
8-Br-cAMP is a cAMP analog that resists hydrolysis by phosphodiesterases, effectively acting as a cAMP agonist. This can enhance PKA signaling, potentially leading to increased activity of TMEM215 through PKA-mediated pathways. | ||||||