TMEM203 Activators
TMEM203 activators can be broadly classified into two categories: those that directly affect intracellular calcium levels and those that influence signaling pathways to achieve similar effects. For instance, Ionomycin is a calcium ionophore that allows calcium to flood into the cell, thereby necessitating the activation of TMEM203 to maintain balanced ER calcium levels. Similarly, Fura-2/AM acts as a calcium indicator but has the added ability to increase cytosolic calcium concentrations, making it a de facto activator of TMEM203 for ER calcium regulation.
In the second category are compounds that modulate specific signaling pathways which indirectly cause TMEM203 activation. For example, PMA activates Protein Kinase C (PKC), which has downstream effects on ER calcium levels, thus triggering TMEM203 for calcium reuptake into the ER. Another example is Calcitriol, the active form of vitamin D3, which promotes intestinal calcium absorption. Increased calcium in the system necessitates cellular adjustments in calcium storage, hence activating TMEM203 to regulate calcium levels within the ER. Both categories serve the core function of activating TMEM203 to regulate intracellular calcium homeostasis, albeit via different mechanisms.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Calcium ionophore that increases intracellular calcium concentrations, thereby necessitating activation of TMEM203 for ER calcium regulation. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Mobilizes calcium from ER by sensitizing ryanodine receptors, leading to increased TMEM203 activity for calcium re-uptake. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Protein synthesis inhibitor that leads to unfolded protein response, requiring TMEM203 activation for calcium homeostasis. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates Protein Kinase C, which can affect ER calcium levels and thereby induce TMEM203 activation. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
PKC inhibitor that increases cytosolic calcium by releasing it from intracellular stores, activating TMEM203 for calcium re-uptake. | ||||||
Kainic acid monohydrate | 58002-62-3 | sc-269283 | 10 mg | $275.00 | ||
Excitatory amino acid that can induce calcium influx, leading to activation of TMEM203 for calcium regulation in the ER. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Activates TRPV1 channels causing calcium influx, activating TMEM203 for calcium regulation within the ER. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
L-type calcium channel agonist, promotes calcium influx necessitating activation of TMEM203 for ER calcium regulation. | ||||||
1-Oleoyl-2-acetyl-sn-glycerol (OAG) | 86390-77-4 | sc-200417 sc-200417A | 10 mg 50 mg | $119.00 $453.00 | 1 | |
Mimics diacylglycerol (DAG), activates PKC, affecting ER calcium and thereby activating TMEM203. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
Active form of vitamin D3, increases intestinal calcium absorption leading to TMEM203 activation for cellular calcium regulation. | ||||||