Molecular structure of 1-Oleoyl-2-acetyl-sn-glycerol (OAG), CAS Number: 86390-77-4
1-Oleoyl-2-acetyl-sn-glycerol (OAG) (CAS 86390-77-4)
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Alternate Names:
1-O-9Z-octadecenoyl-2-O-acetyl-sn-glycerol; OAG
Application:
1-Oleoyl-2-acetyl-sn-glycerol (OAG) is a protein kinase C activating diacylglycerol
CAS Number:
86390-77-4
Purity:
≥90%
Molecular Weight:
398.6
Molecular Formula:
C23H42O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1-Oleoyl-2-acetyl-sn-glycerol (OAG) is a synthetic, membrane-permeable diacylglycerol analog demonstrated to activate PKC (Ca2+-dependent protein kinase C). Playing a significant role in cellular processes, 1-Oleoyl-2-acetyl-sn-glycerol (OAG) is a naturally occurring lipid found in cells. Its involvement in gene expression regulation, cell signaling, and metabolism has been observed. Composed of three fatty acid molecules attached to the glycerol backbone, it is a component of the cell membrane′s phospholipid bilayer. It participates in regulating metabolic pathways such as glycolysis and fatty acid oxidation.
1-Oleoyl-2-acetyl-sn-glycerol (OAG) (CAS 86390-77-4) References
- Activation of protein kinase C alpha enhances human growth hormone-binding protein release. | Saito, Y., et al. 1998. Mol Cell Endocrinol. 146: 197-205. PMID: 10022777
- Metabolism of [14C]arachidonic acid-labeled lipids in quiescent and OAG-stimulated ascites tumor cells. | Haeffner, EW. and Strosznajder, JB. 1992. Int J Biochem. 24: 1481-5. PMID: 1426529
- Receptor-operated Ca2+ entry mediated by TRPC3/TRPC6 proteins in rat prostate smooth muscle (PS1) cell line. | Thebault, S., et al. 2005. J Cell Physiol. 204: 320-8. PMID: 15672411
- A TRPC-like non-selective cation current activated by alpha 1-adrenoceptors in rat mesenteric artery smooth muscle cells. | Hill, AJ., et al. 2006. Cell Calcium. 40: 29-40. PMID: 16697039
- Protein kinase activator 1-oleoyl-2-acetyl-sn-glycerol inhibits two types of calcium currents in GH3 cells. | Marchetti, C. and Brown, AM. 1988. Am J Physiol. 254: C206-10. PMID: 2447796
- Effects of exogenous phospholipase enzymes, arachidonic acid and 1-oleoyl-2-acetyl-sn-glycerol on ketogenesis in isolated rat hepatocytes. | Chihara, M., et al. 1989. Biochim Biophys Acta. 1012: 5-9. PMID: 2499356
- Effect of 1-oleoyl-2-acetyl-sn-glycerol on inositol lipid metabolism of ascites tumor cells in culture. | Strosznajder, JB. and Haeffner, EW. 1989. J Lipid Mediat. 1: 175-87. PMID: 2562433
- Partial dependency of 1-oleoyl-2-acetyl-glycerol-induced superoxide production by human neutrophils on calcium ions and cytochalasin B. | Ozaki, Y., et al. 1986. Biochem Biophys Res Commun. 134: 690-7. PMID: 3004460
- Guanine nucleotides activate cytosolic phospholipase C of ascites tumour cells stimulated by 1-oleoyl-2-acetyl-sn-glycerol. | Strosznajder, J. and Haeffner, EW. 1988. Int J Tissue React. 10: 291-6. PMID: 3250942
- Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation. | Kaibuchi, K., et al. 1983. J Biol Chem. 258: 6701-4. PMID: 6406488
- Fluid shear stress stimulates platelet-derived growth factor expression in endothelial cells. | Mitsumata, M., et al. 1993. Am J Physiol. 265: H3-8. PMID: 8342646
- Activation of protein kinase C augments peptide release from rat sensory neurons. | Barber, LA. and Vasko, MR. 1996. J Neurochem. 67: 72-80. PMID: 8667028
- Protein kinase C regulates Fas (CD95/APO-1) expression. | Wang, R., et al. 1998. J Immunol. 161: 2201-7. PMID: 9725212
Inhibitor of:
DGK-η, and PITPβ.Activator of:
5730419I09Rik, ACTR-IC, ARMC5, Arylsulfatase F, C17orf39_4933439F18Rik, CaMKIγ, CaMKIIα, CASK, CAT56, CD1B3, Chromozym PL, CNIH, cPKC γ, DGK-α, EF-CAB7, EF-HC1, EG631584, Enkurin, ENSMUSG00000071517, KIAA1683, LOC100131244, LOC100131781, LOC100132288, LOC100132292, LOC100132418, LOC100132713, LOC100133257, LOC100133301, LOC100133893, LOC100271928, LOC100287718, LOC100302688, LOC158830, LOC259308, LOC374973, LOC387763, LOC388588, LOC389493, LOC401387, LOC440957, LOC498735, LOC644613, LOC646802, LOC689425, LOC728129, LOC729832, LOC732391, LRRC64, Ly-49N, MAGE-3, MARVELD3, MPP4, Munc13-1, Munc13-2, Na+ CP type VIIα, neurexin I, NKHC1, Olfr462, Olfr463, Olfr464, Olr1397, Olr1404, Olr1413, Olr1431, Olr1433, Olr1462, Olr1472, Olr1488, Olr150, Olr1513, ORP-11, OS4, Peroxin 1, PKC, PKC γ, PKC ζII, PLC δ4, PLC η2, PLC ζ, plexin-D1, Pma, PNRC1, PRK1, RasGRP4, RGD1562043, RGL1, Synaptotagmin I/II, TMEM16J, TMEM203, TMEM24, TRPC4, TRPM2, TRPV5, VibH, and zinedin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-Oleoyl-2-acetyl-sn-glycerol (OAG), 10 mg | sc-200417 | 10 mg | $117.00 | |||
1-Oleoyl-2-acetyl-sn-glycerol (OAG), 50 mg | sc-200417A | 50 mg | $444.00 |