TMEM2 Activators

Cell migration-inducing hyaluronidase 2 (CEMIP2), also known as hyaluronidase 2 (Hyal2), is an enzyme that belongs to the hyaluronidase family, which plays a critical role in the degradation of hyaluronic acid (HA). HA is a major component of the extracellular matrix (ECM) and is involved in many physiological and pathological processes, including cell adhesion, migration, proliferation, and inflammation.CEMIP2 is encoded by the HYAL2 gene in humans and is anchored to the cell membrane, where it can exert its enzymatic activity. This enzyme is unique among hyaluronidases due to its ability to degrade high molecular weight HA into intermediate-sized HA fragments rather than into monosaccharides, as other hyaluronidases do. These HA fragments can then modulate signaling pathways that are crucial for cell migration and tissue remodeling.

The function of CEMIP2 is not only limited to the degradation of HA but also involves the regulation of various cell behaviors. It has been implicated in the process of angiogenesis, which is the formation of new blood vessels from pre-existing ones, a vital process for tissue growth and repair. Furthermore, CEMIP2 is involved in cancer pathogenesis, as its expression can be altered in tumor cells, influencing tumor growth, metastasis, and the tumor microenvironment.In the context of disease, the altered expression or activity of CEMIP2 has been associated with the progression of certain cancers, fibrosis, and other disorders where ECM remodeling plays a significant role.