TMEM190 Inhibitors
Chemical inhibitors of TMEM190 can exert their effects through a variety of mechanisms, each specific to the signaling pathways they target. Staurosporine, a broad-spectrum protein kinase inhibitor, can inhibit TMEM190 by preventing the phosphorylation events typically required for the protein's activity. Similarly, Bisindolylmaleimide I, which selectively inhibits protein kinase C, can reduce TMEM190 activity by halting PKC-mediated signaling cascades. LY294002 and Wortmannin, both inhibitors of phosphoinositide 3-kinases, can disrupt the PI3K/AKT pathway, impeding the cellular processes that may be crucial for the functional activity of TMEM190. PD98059 and SB203580, which inhibit MEK and p38 MAP kinase respectively, can interfere with the MAPK/ERK and p38 MAPK signaling pathways, leading to diminished TMEM190 function as these pathways are often essential for the regulation of protein activities within the cell.
Continuing with the theme of targeted inhibition, U73122 can inhibit TMEM190 by impeding phospholipase C, whose downstream signaling is sometimes necessary for protein function. Gö 6983, a pan-PKC inhibitor, can decrease TMEM190 activity by disrupting PKC-dependent signaling. PP2, a Src family tyrosine kinase inhibitor, can inhibit the Src kinase-mediated pathways that TMEM190 may utilize for its activity. SP600125 inhibits c-Jun N-terminal kinase, and by doing so, it can interfere with JNK signaling, which may play a role in regulating TMEM190 activity. ML7 targets myosin light chain kinase, and its inhibition could lead to reduced TMEM190 activity if TMEM190 relies on MLCK-dependent pathways. Lastly, KN-93, which inhibits calcium/calmodulin-dependent protein kinase II, can hinder calcium signaling pathways, thereby leading to the inhibition of TMEM190, assuming that TMEM190's activity is regulated by CaMKII-mediated signaling events.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. By inhibiting multiple kinases that are upstream regulators or activators of TMEM190, staurosporine can inhibit the phosphorylation events required for TMEM190's functional activity. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I selectively inhibits protein kinase C (PKC). Since PKC is involved in signal transduction pathways that can regulate the activity of TMEM190, its inhibition can lead to reduced functionality of TMEM190. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, LY294002 disrupts the PI3K/AKT pathway, which could be crucial for TMEM190-mediated signaling, thereby inhibiting TMEM190's function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which inhibits the MAPK/ERK pathway. Since the MAPK/ERK pathway may be necessary for TMEM190 function, PD98059 can inhibit TMEM190 activity through this mechanism. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. By inhibiting p38 MAP kinase, SB203580 can disrupt cellular processes that rely on p38 MAPK signaling, which may be essential for the activity of TMEM190, thus leading to its inhibition. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K. By inhibiting PI3K, Wortmannin can disrupt signaling pathways that are potentially necessary for TMEM190's functional activity, leading to its inhibition. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Gö 6983 is a pan-PKC inhibitor. By targeting multiple PKC isoforms, Gö 6983 can decrease TMEM190 activity through the inhibition of PKC-dependent signaling pathways that TMEM190 might utilize. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family tyrosine kinases. It can inhibit TMEM190 by disrupting Src kinase-mediated signaling pathways that are essential for TMEM190's activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). By inhibiting JNK, SP600125 can inhibit TMEM190 by interfering with JNK signaling pathways that may regulate TMEM190's activity. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML7 is an inhibitor of myosin light chain kinase (MLCK). Inhibition of MLCK by ML7 can lead to the inhibition of TMEM190 if TMEM190's function is regulated by MLCK-dependent pathways. | ||||||