TMEM190 Activators
TMEM190 can engage various intracellular signaling pathways to initiate its activation. Forskolin is one such activator, directly targeting adenylate cyclase to increase the levels of cyclic AMP (cAMP) within the cell. This rise in cAMP leads to the activation of protein kinase A (PKA), which can phosphorylate TMEM190, thereby altering its activity. Similarly, IBMX works by inhibiting phosphodiesterases, the enzymes responsible for breaking down cAMP, thus sustaining and amplifying the PKA-mediated phosphorylation of TMEM190. Prostaglandin E2 (PGE2) operates through a related mechanism, binding to its G-protein-coupled receptors (GPCRs) and triggering an increase in cAMP, which, in turn, activates PKA and the subsequent phosphorylation of TMEM190.
TMEM190 through calcium-dependent mechanisms. Ionomycin acts as a calcium ionophore, increasing intracellular calcium, which can activate specific calcium-dependent kinases capable of phosphorylating TMEM190. Thapsigargin disrupts calcium homeostasis by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), again leading to elevated cytosolic calcium levels that may activate kinases targeting TMEM190. A23187, also a calcium ionophore, raises intracellular calcium concentration, potentially facilitating the activation of TMEM190 through calcium-dependent pathways. BAY K8644 further contributes to this elevation by acting as a calcium channel agonist, enhancing calcium influx. This influx of calcium can activate TMEM190 indirectly through the activation of calcium-dependent kinases. Additionally, bradykinin, through its receptor, can activate phospholipase C (PLC), increasing the levels of inositol trisphosphate (IP3) and diacylglycerol (DAG), secondary messengers that also have roles in the regulation of intracellular calcium and the activation of TMEM190. Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which is known to phosphorylate a range of protein targets including TMEM190. Lastly, zinc sulfate can influence TMEM190 activity by modulating the function of kinases and proteins that interact with TMEM190, while ouabain by inhibiting the Na+/K+ ATPase, indirectly affects calcium homeostasis and potentially TMEM190 activity via calcium-dependent signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Isobutylmethylxanthine (IBMX) inhibits phosphodiesterases, preventing cAMP breakdown, which could sustain the activation of TMEM190 through cAMP-dependent pathways. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) binds to its G-protein-coupled receptors (GPCRs), leading to increased intracellular cAMP levels, which can activate PKA and subsequently TMEM190. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases (SAPKs), potentially leading to the phosphorylation and activation of TMEM190 as part of the cellular stress response. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which may activate calcium-dependent kinases that phosphorylate and activate TMEM190. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased cytosolic calcium levels and potential activation of calcium-dependent kinases that could phosphorylate and activate TMEM190. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium concentration, potentially activating calcium-dependent pathways that lead to the activation of TMEM190. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin activates its GPCR, which leads to the activation of phospholipase C (PLC), increasing inositol trisphosphate (IP3) and diacylglycerol (DAG), secondary messengers that can lead to the activation of TMEM190. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can phosphorylate and activate TMEM190. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc can act as a signaling molecule, potentially interacting with regulatory domains of proteins and kinases that could lead to the phosphorylation and activation of TMEM190. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
BAY K8644 is a calcium channel agonist that increases calcium influx, possibly activating calcium-dependent kinases, which could lead to the activation of TMEM190. | ||||||