TMEM179B Inhibitors
TMEM179B inhibitors encompass a variety of chemical compounds that influence specific signaling pathways or biological processes to lead to the functional inhibition of TMEM179B. The mechanisms by which these inhibitors operate are diverse, yet each has a distinct impact on cellular processes that can indirectly affect TMEM179B activity. For instance, compounds like rapamycin and LY294002 target the mTOR and PI3K/Akt pathways, respectively, which are crucial for protein synthesis and cell survival. The inhibition of these pathways can result in a decrease in the overall stability and activity of TMEM179B, as mTOR plays a pivotal role in the regulation of protein synthesis and autophagy, processes that are intimately connected with the functionality and expression of various proteins, including TMEM179B.
In addition to these, other compounds such as PD98059, SB203580, and SP600125 inhibit different kinases within the MAPK signaling pathway, which is known to modulate cellular growth and stress responses. Altered signaling through these pathways can impact the transcriptional and translational mechanisms that govern the expression and functionality of TMEM179B.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin selectively binds to FKBP12 and the complex inhibits mTOR, a kinase that is upstream of processes involving TMEM179B. mTOR inhibition can lead to reduced protein synthesis and autophagy induction, which may decrease the functional activity of TMEM179B due to enhanced degradation or reduced protein synthesis. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K). PI3K inhibition disrupts the Akt/mTOR pathway, which is involved in protein synthesis and cellular survival. This disruption can diminish the synthesis or stability of proteins such as TMEM179B. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another inhibitor of PI3K, leading to the blockade of the PI3K/Akt pathway. The inhibition of this pathway can reduce the activity of downstream effectors such as mTOR, potentially diminishing the activity or expression of TMEM179B. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $56.00 $256.00 | 113 | |
3-Methyladenine is known to inhibit autophagy through its action on class III PI3K. While autophagy inhibition might initially seem contradictory, prolonged autophagy inhibition can disrupt cellular homeostasis and degrade proteins indirectly, affecting proteins like TMEM179B. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which acts upstream of ERK in the MAPK pathway. The inhibition of this pathway can alter cellular growth signals, potentially affecting the stability and function of TMEM179B. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. Inhibition of p38 MAPK can lead to altered stress responses and cytokine production, which may indirectly affect the stability and function of TMEM179B. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which is part of the MAPK signaling pathway. Inhibition of JNK can affect transcription factors and cellular stress responses, potentially reducing the functional activity of TMEM179B. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 specifically inhibits V-ATPase, which can disrupt lysosomal acidification and autophagy. Disruption of these processes can lead to altered protein degradation pathways, potentially affecting TMEM179B stability. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine inhibits autophagy by raising the lysosomal pH. The inhibition of autophagy can result in the accumulation of dysfunctional proteins and organelles, which may indirectly decrease the functional activity of TMEM179B. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that can lead to the accumulation of polyubiquitinated proteins. This accumulation could interfere with the degradation pathway of TMEM179B, affecting its functional activity. | ||||||