TMEM110 Inhibitors
The function of TMEM110, synonymous with STIMATE, is intertwined with store-operated calcium entry (SOCE), a quintessential mechanism regulating intracellular calcium dynamics. Chemical inhibitors tailored towards SOCE and other calcium-associated pathways present avenues to modulate TMEM110's function indirectly. SKF-96365 and 2-APB, by targeting receptor-mediated calcium channels and IP3 receptors respectively, serve as potent modulators of SOCE, subsequently impacting TMEM110's role in the pathway. Furthermore, CRAC channels, vital components of SOCE, when inhibited by compounds like BTP2 or GSK-7975A, lead to an alteration in calcium dynamics, a change that can shape the functional characteristics of TMEM110.
Moreover, Xestospongin C, a potent IP3 receptor inhibitor, plays a vital role in altering calcium release from the ER, an action that might hold repercussions for TMEM110's modulatory function. In a broader perspective, calcium channel inhibitors such as Econazole, Miconazole, and Carboxyamidotriazole emphasize the widespread strategies that can be adopted to regulate calcium homeostasis. With this plethora of inhibitors, targeting diverse aspects of the calcium signaling pathway, the indirect modulation of TMEM110 becomes plausible.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
Inhibitor of receptor-mediated calcium entry channels. By inhibiting SOCE, it can indirectly modulate the function of TMEM110. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
Modulates IP3 receptors and TRP channels and can inhibit SOCE. Its influence on SOCE can potentially modulate TMEM110 function. | ||||||
CRAC Channel Inhibitor, BTP2 | 223499-30-7 | sc-221441 | 5 mg | $185.00 | 9 | |
Potent inhibitor of CRAC channels, which are involved in SOCE. Its action on CRAC can indirectly influence TMEM110. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $110.00 $440.00 $660.00 $1200.00 | 2 | |
Inhibitor of myosin light chain kinase, affecting calcium signaling and potentially influencing TMEM110 indirectly. | ||||||
Xestospongin C | 88903-69-9 | sc-201505 | 50 µg | $500.00 | 14 | |
IP3 receptor inhibitor, which modulates calcium release from the ER. By altering calcium dynamics, TMEM110 function can be influenced. | ||||||
Econazole | 27220-47-9 | sc-279013 | 5 g | $240.00 | ||
Inhibitor of SOCE, and thus, can indirectly modulate the function of TMEM110. | ||||||
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $65.00 $157.00 | 2 | |
Another SOCE inhibitor, which can potentially affect TMEM110 function. | ||||||
TMB-8 • HCl | 53464-72-5 | sc-3522 sc-3522A | 10 mg 50 mg | $42.00 $126.00 | 10 | |
Inhibitor of intracellular calcium release. Its action on calcium signaling can influence TMEM110 indirectly. | ||||||
L-651,582 | 99519-84-3 | sc-204039 sc-204039A | 10 mg 50 mg | $185.00 $781.00 | ||
Non-selective calcium channel inhibitor, which can modulate calcium dynamics and indirectly influence TMEM110. | ||||||