Molecular structure of TMB-8 • HCl, CAS Number: 53464-72-5
TMB-8 • HCl (CAS 53464-72-5)
See product citations (10)
Alternate Names:
8-(Diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride; 3,4,5-Trimethoxybenzoic acid 8-(diethylamino)octyl ester hydrochloride
Application:
TMB-8 • HCl is a PKC inhibitor and a calcium and sodium channel blocker
CAS Number:
53464-72-5
Purity:
≥98%
Molecular Weight:
431.99
Molecular Formula:
C22H37NO5•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
TMB-8•HCl is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ antagonist. TMB-8•HCl possesses both Ca2+ channel- and Na+ channel-blocking properties and reduces the membrane K+ conductance. Shown to nonselectively inhibit membrane currents in single isolated guinea pig ventricular cardiomyocytes and to inhibit 5-hydroxytryptamine type 3A (5-HT3A, SR-3A) receptor-mediated currents. TMB-8•HCl inhibits platelet-activating factors (PAF) and PMA-stimulated prostaglandin production in Kupffer cells. Research shows that TMB-8•HCl accumulates at the lipid-water interphase of biologic membranes and therefore interferes with the normal function of many membrane proteins. A useful tool to distinguish dependence on intracellular versus extracellular Ca2+.
TMB-8 • HCl (CAS 53464-72-5) References
- [8-(Diethylamino)octyl-3,4,5-trimethoxybenzoate, HCl], the inhibitor of intracellular calcium mobilization, blocked mitogen-induced T cell proliferation by interfering with the sustained phase of protein kinase C activation. | Kumar, S. and Chakrabarti, R. 2000. J Cell Biochem. 76: 539-47. PMID: 10653973
- Platelet-activating factor-mediated synthesis of prostaglandins in rat Kupffer cells. | Gandhi, CR., et al. 1992. Biochim Biophys Acta. 1136: 68-74. PMID: 1322709
- Inhibition of interleukin 1-induced biosynthesis of stromelysin by the calcium antagonist TMB-8 (8-(N, N-diethylamino)octyl-3,4,5-trimethoxybenzoate HCl). | Baragi, VM., et al. 1995. Connect Tissue Res. 31: 153-60. PMID: 15612331
- Abrogation of DTH response and mitogenic lectin- and alloantigen-induced activation of lymphocytes by calcium inhibitors TMB-8 and BAPTA-AM. | Saxena, HM. and Dikshit, M. 2005. Immunol Lett. 101: 60-4. PMID: 15893385
- Influence of TMB-8 and thapsigargin on vasoconstrictor responses in the pulmonary vascular bed of the cat. | Ibrahim, IN., et al. 2005. Am J Ther. 12: 411-6. PMID: 16148426
- TMB-8 as a pharmacologic tool in guinea pig myocardial tissues. I. Effects of TMB-8 on force of contraction and on action potential parameters in atrial and papillary muscles. | Himmel, HM. and Ravens, U. 1990. J Pharmacol Exp Ther. 255: 293-9. PMID: 1698970
- TMB-8 as a pharmacologic tool in guinea pig myocardial tissues. II. Effects of TMB-8 on membrane currents in isolated ventricular cardiomyocytes. | Himmel, HM. and Ravens, U. 1990. J Pharmacol Exp Ther. 255: 300-4. PMID: 1698971
- A role for the Val291 residue within the transmembrane domain 2 in diltiazem- and TMB-8 [3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester]-mediated 5-hydroxytryptamine type 3A receptor regulations. | Lee, BH., et al. 2009. Biol Pharm Bull. 32: 861-7. PMID: 19420755
- Effects of calcium antagonist TMB-8 on active Na and Cl transport in rabbit ileum. | Donowitz, M., et al. 1986. Am J Physiol. 250: G691-7. PMID: 3010736
- Effects of 8-N,N-diethylamino-octyl-3,4,5-trimethoxybenzoate (TMB-8) HCl and verapamil on the metabolism of free fatty acid by hepatocytes. | Olubadewo, JO., et al. 1988. Biochem Pharmacol. 37: 1463-71. PMID: 3358779
- Inhibition of protein kinase C activation by 8-(N,N-diethylamino)-octyl-3, 4, 5-trimethoxybenzoate (TMB-8), an intracellular Ca2+ antagonist. | Sawamura, M. 1985. Kobe J Med Sci. 31: 221-32. PMID: 3831591
- Effect of TMB-8 on the pulmonary vasoconstrictor action of prostaglandin F2 alpha and the thromboxane mimic, U 46619. | Angerio, AD., et al. 1982. Br J Pharmacol. 77: 55-8. PMID: 6957253
- Effects of 8-(N, N-diethylamino)ocytl 3, 4, 5-trimethoxybenzoate HCl (TMB-8) on washed blood platelets with special reference to a specific loss of serotonin. | Mürer, EH. and Siojo, E. 1982. Thromb Haemost. 47: 59-61. PMID: 7071807
Inhibitor of:
2610021K21Rik, 4930408G06Rik, 4931407G18Rik, 5730419I09Rik, BSPII, Calcium Channel Protein, CALR3, Centrin, Centrin-3, CUTA, DANGER, Dear, DOC2A, EG667094, Gm5849, Grancalcin, HRC, IP3KB, IP3R-III, ITPRIPL2, JP-45, MCTP2, neurocalcin δ, Olfr448, Olfr459, PKC, PMCA3, S-100P, Sodium Channel Protein, ST8Sia IV, Stim2, TMEM110, TMEM184B, TMEM38A, TMEM66, VILIP-2, and Vmn1r224.Activator of:
CaBP5, Calretinin, EF-CAB2, IPMK, Orai3, PMCA2, and TMEM38B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TMB-8 • HCl, 10 mg | sc-3522 | 10 mg | $43.00 | |||
TMB-8 • HCl, 50 mg | sc-3522A | 50 mg | $129.00 |