Molecular structure of Xestospongin C, CAS Number: 88903-69-9
Xestospongin C (CAS 88903-69-9)
See product citations (14)
Alternate Names:
Araguspongin E
Application:
Xestospongin C is a potent, membrane-permeable IP3 receptor blocker
CAS Number:
88903-69-9
Purity:
≥90%
Molecular Weight:
446.71
Molecular Formula:
C28H50N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Xestospongin C is recognized for its role as a potent inhibitor of inositol triphosphate (IP3) receptors, which are intracellular channels responsible for the release of calcium ions from storage within cells. It used as a biological tool to study calcium signaling pathways, providing insights into the mechanisms by which cells regulate calcium levels and the effects of calcium dysregulation. Xestospongin C is used in the field of neurobiology, where understanding calcium homeostasis is for exploring neuronal function and communication.
Xestospongin C (CAS 88903-69-9) References
- Xestospongin C, a selective and membrane-permeable inhibitor of IP(3) receptor, attenuates the positive inotropic effect of alpha-adrenergic stimulation in guinea-pig papillary muscle. | Miyamoto, S., et al. 2000. Br J Pharmacol. 130: 650-4. PMID: 10821794
- Ca2+ entry mediated by store depletion, S-nitrosylation, and TRP3 channels. Comparison of coupling and function. | van Rossum, DB., et al. 2000. J Biol Chem. 275: 28562-8. PMID: 10878007
- Xestospongin C is an equally potent inhibitor of the inositol 1,4,5-trisphosphate receptor and the endoplasmic-reticulum Ca(2+) pumps. | De Smet, P., et al. 1999. Cell Calcium. 26: 9-13. PMID: 10892566
- Modulation of early [Ca2+]i rise in metabolically inhibited endothelial cells by xestospongin C. | Schäfer, M., et al. 2001. Am J Physiol Heart Circ Physiol. 280: H1002-10. PMID: 11179041
- Capacitative Ca(2+) entry in vascular endothelial cells is mediated via pathways sensitive to 2 aminoethoxydiphenyl borate and xestospongin C. | Bishara, NB., et al. 2002. Br J Pharmacol. 135: 119-28. PMID: 11786487
- Xestospongin C, a novel blocker of IP3 receptor, attenuates the increase in cytosolic calcium level and degranulation that is induced by antigen in RBL-2H3 mast cells. | Oka, T., et al. 2002. Br J Pharmacol. 135: 1959-66. PMID: 11959799
- Xestospongin C is a potent inhibitor of SERCA at a vertebrate synapse. | Castonguay, A. and Robitaille, R. 2002. Cell Calcium. 32: 39-47. PMID: 12127061
- Xestospongin C empties the ER calcium store but does not inhibit InsP3-induced Ca2+ release in cultured dorsal root ganglia neurones. | Solovyova, N., et al. 2002. Cell Calcium. 32: 49-52. PMID: 12127062
- Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle. | Ozaki, H., et al. 2002. Br J Pharmacol. 137: 1207-12. PMID: 12466229
- Acute exposure to methylmercury causes Ca2+ dysregulation and neuronal death in rat cerebellar granule cells through an M3 muscarinic receptor-linked pathway. | Limke, TL., et al. 2004. Toxicol Sci. 80: 60-8. PMID: 15141107
- Inositol trisphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation. | Wilkerson, MK., et al. 2006. Am J Physiol Heart Circ Physiol. 290: H240-7. PMID: 16113072
- Xestospongin C induces monocytic differentiation of HL60 cells through activation of the ERK pathway. | Moon, DO., et al. 2013. Food Chem Toxicol. 55: 505-12. PMID: 23395717
- Xestospongin C, a Reversible IP3 Receptor Antagonist, Alleviates the Cognitive and Pathological Impairments in APP/PS1 Mice of Alzheimer's Disease. | Wang, ZJ., et al. 2019. J Alzheimers Dis. 72: 1217-1231. PMID: 31683484
- Mechanism of Oxytocin-Induced Contraction in Rat Gastric Circular Smooth Muscle. | Alqudah, M., et al. 2022. Int J Mol Sci. 24: PMID: 36613886
- Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor. | Gafni, J., et al. 1997. Neuron. 19: 723-33. PMID: 9331361
Inhibitor of:
4930408G06Rik, 9130409J20Rik, AHCYL2, C2CD4D, C6orf105, C8β, CALR3, calsequestrin 1, CHERP, DANGER, EFR3B, EG666504, EG667094, EG667472, EG667543, Enkurin, Gβ 3, Homer-1, HRC, IP3KA, IP3R-I, IP3R-III, ITPRIPL1, ITPRIPL2, JAML, Junctophilin-4, MCTP1, MCTP2, Nir1, NRF-1, Olfr1046, Olfr1057, Olfr108, Olfr1101, Olfr491, Olfr493, Olfr494, Olfr71, Olfr710, Olfr711, Olfr871, Olfr872, Olfr873, Olfr90, PDZK4, reticulocalbin-3, SNT-2, Stim2, syncytin, TMCO5, TMCO7, TMEM102, TMEM110, TMEM203, TMEM229B, TMEM24, TMEM38A, TMEM80, TMEM86B, TMTC2, TMTC3, V1RB9, V1RG4, V1RG5, V1RH2, V1RH4, Vmn1r100, Vmn1r104, Vmn1r125, Vmn1r224, Vmn1r91, Vmn1r92, Vmn2r15, Vmn2r85, and VRL-1.Activator of:
CaBP5, CLRN2, CRISP-4, DAP-4, ELKS, IPMK, ITPK1, Junctional SR Marker, Orai3, PMCA4b, reticulocalbin-1, RyR-1, Smooth muscle cells, TPCN1, and TPCN2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Xestospongin C, 50 µg | sc-201505 | 50 µg | $500.00 |