TMEM107 Inhibitors
TMEM107 inhibitors target various aspects of cellular physiology that can impact the activity of TMEM107 on a functional level. Compounds like Genistein, W-7 Hydrochloride, and LY294002 act on signaling pathways by inhibiting tyrosine kinases, antagonizing calmodulin, and blocking phosphoinositide 3-kinases (PI3K), respectively. These actions can alter downstream pathways, leading to changes in the activity or expression of transmembrane proteins including TMEM107.
Amiloride and Ouabain work by altering ion transport across cellular membranes, which is a fundamental process affecting the function of many membrane proteins. Brefeldin A, Dynasore, and Endosidin 2 are involved in the inhibition of vesicle trafficking, which is crucial for the proper localization and turnover of membrane proteins such as TMEM107. Ionomycin and Niflumic Acid disrupt ion homeostasis, which is essential for the activity of ion-sensitive transmembrane proteins. DIDS and Monensin alter the ion balance across the membrane, impacting the function of transmembrane proteins by changing the electrochemical gradient.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Tyrosine kinase inhibitor; can inhibit phosphorylation events in signaling pathways. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
Calmodulin antagonist; can disrupt calcium signaling involving transmembrane proteins. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $296.00 | 7 | |
Sodium channel blocker; can alter ion flux across membranes, affecting TMEM107 indirectly. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Inhibitor of vesicle trafficking; can disrupt protein transport and membrane composition. | ||||||
DIDS, Disodium Salt | 67483-13-0 | sc-203919A sc-203919B sc-203919 sc-203919C | 25 mg 100 mg 250 mg 1 g | $51.00 $163.00 $286.00 $683.00 | 6 | |
Anion channel inhibitor; can alter transmembrane ion balance impacting protein function. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynamin inhibitor; can impede vesicle scission, potentially affecting TMEM107 localization. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Calcium ionophore; can disrupt calcium homeostasis and related transmembrane protein activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor; can alter intracellular signaling potentially affecting TMEM107. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Ionophore that disrupts ionic gradients; can change transmembrane potential affecting proteins. | ||||||
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $32.00 | 3 | |
Chloride channel blocker; can modify ion transport and membrane potential. | ||||||