DIDS, Disodium Salt CAS: 67483-13-0
MF: C16H8N2O6S4•2Na
MW: 498.50

DIDS, Disodium Salt (CAS 67483-13-0)

DIDS, Disodium Salt | CAS 67483-13-0 is rated 5.0 out of 5 by 1.
  • y_2020, m_12, d_2, h_16
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_203919, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 128ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Alternate Names: DIDS, Disodium Salt is known as a stilbene sulfonate anionic transport inhibitor.
Application: DIDS, Disodium Salt is an anion transport inhibitor that inhibits Cl- uptake through plasma membrane-localized Cl- channels.
CAS Number: 67483-13-0
Purity: ≥80%
Molecular Weight: 498.50
Molecular Formula: C16H8N2O6S42Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

DIDS, Disodium Salt binds covalently and irreversibly to the outer surface of human erythrocyte membranes. DIDS, Disodium Salt is known to inhibit ATP transport into endoplasmic reticulum vesicles. DIDS, Disodium Salt is an anion transport inhibitor that inhibits Cl– uptake (IC50 = 150 nM) in neuroblastoma cells. DIDS, Disodium Salt has anti-ulcerous properties. Sodium-coupled bicarbonate transporters are also effectively inhibited by DIDS, Disodium Salt.


References

1. Bettendorff, L., et al. 1995. Biochem. Biophys. Res. Commun. 207, 375.
2. Horie, S., et al. 1993. Res. Commun. Chem. Pathol. Pharmacol. 79, 117.
3. Mayinger, P., and Meyer, D.I. 1993. EMBO J. 12, 659.
4. Catantchik, Z.I., and Rothstein, A. 1974. J. Membr. Biol. 15, 207.
5. Pusch, M., Zifarelli, G., Murgia, A., et al.Channel or transporter? The CLC saga continues. Experimental Physiology 91(1), 149-152 (2006).
6. Boron, W.F.Sodium-coupled bicarbonate transporters. Journal of the Pancreas 2(4 Suppl), 176-181 (2001).

Physical State :
Solid
Solubility :
Soluble in water, methanol, DMSO, and 0.1 M potassium bicarbonate (50 mg/ml).
Storage :
Store at -20° C
Melting Point :
>300° C (dec.)
IC50 :
Cl– uptake: IC50 = 150 nM (neuroblastoma cells)
pK Values :
pKa: -1.43 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5702690
MDL Number :
MFCD00009638
Beilstein Registry :
8179433
SMILES :
C1=CC(=C(C=C1N=C=S)S(=O)(=O)[O-])C=CC2=C(C=C(C=C2)N=C=S)S(=O)(=O)[O-].[Na+].[Na+]

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

DIDS, Disodium Salt (CAS 67483-13-0)  Product Citations

See how others have used DIDS, Disodium Salt (CAS 67483-13-0). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 26038755  Ren, P. et al. 2014. Emerg Microbes Infect. 3: e62.

PMID: # 28461573  J. Immunol. 198: 4255-4267.

PMID: # 32154964  Cancer Sci. 111: 1794-1804.

Citations 1 to 3 of 3 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 138ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Shen Shen, B. et al. (PubMed 26356265) used the anion transport inhibitor, DIDS, to demonstrate that Na+-K+-2Cl- cotransporter 1 is involved in the formation of phenylephrine-induced rhythmic contraction. -SCBT Publication Review
Date published: 2015-06-19
  • y_2020, m_12, d_2, h_16
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_203919, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 6ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.