Molecular structure of DIDS, Disodium Salt, CAS Number: 67483-13-0
DIDS, Disodium Salt (CAS 67483-13-0)
See product citations (6)
Alternate Names:
DIDS, Disodium Salt is known as a stilbene sulfonate anionic transport inhibitor.
Application:
DIDS, Disodium Salt is an anion transport inhibitor that inhibits Cl- uptake through plasma membrane-localized Cl- channels.
CAS Number:
67483-13-0
Purity:
≥80%
Molecular Weight:
498.50
Molecular Formula:
C16H8N2O6S4•2Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
DIDS, Disodium Salt binds covalently and irreversibly to the outer surface of human erythrocyte membranes. DIDS, Disodium Salt is known to inhibit ATP transport into endoplasmic reticulum vesicles. DIDS, Disodium Salt is an anion transport inhibitor that inhibits Cl– uptake (IC50 = 150 nM) in neuroblastoma cells. DIDS, Disodium Salt has anti-ulcerous properties. Sodium-coupled bicarbonate transporters are also effectively inhibited by DIDS, Disodium Salt.
DIDS, Disodium Salt (CAS 67483-13-0) References
- Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver. | Mandon, EC., et al. 1992. J Biol Chem. 267: 11144-8. PMID: 1317856
- The role of anion channels and Ca2+ in addition to K+ channels in the physiological volume regulation of murine spermatozoa. | Yeung, CH., et al. 2005. Mol Reprod Dev. 71: 368-79. PMID: 15803461
- Discovery of potent CLC chloride channel inhibitors. | Matulef, K., et al. 2008. ACS Chem Biol. 3: 419-28. PMID: 18642799
- Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. | Ma, W., et al. 2009. J Pharmacol Exp Ther. 328: 409-18. PMID: 19023039
- Chloride channel conductance is required for NGF-induced neurite outgrowth in PC12 cells. | Kim, SY., et al. 2010. Neurochem Int. 56: 663-9. PMID: 20144672
- Glycogen synthase kinase 3-mediated voltage-dependent anion channel phosphorylation controls outer mitochondrial membrane permeability during lipid accumulation. | Martel, C., et al. 2013. Hepatology. 57: 93-102. PMID: 22814966
- Considering effects of nanosecond pulsed electric fields on proteins. | Beebe, SJ. 2015. Bioelectrochemistry. 103: 52-9. PMID: 25218277
- Inhibition of VDAC1 prevents Ca²⁺-mediated oxidative stress and apoptosis induced by 5-aminolevulinic acid mediated sonodynamic therapy in THP-1 macrophages. | Chen, H., et al. 2014. Apoptosis. 19: 1712-26. PMID: 25342393
- A Purified Resin Glycoside Fraction from Pharbitidis Semen Induces Paraptosis by Activating Chloride Intracellular Channel-1 in Human Colon Cancer Cells. | Zhu, D., et al. 2019. Integr Cancer Ther. 18: 1534735418822120. PMID: 30614302
- Saccharomyces cerevisiae: First Steps to a Suitable Model System To Study the Function and Intracellular Transport of Human Kidney Anion Exchanger 1. | Sarder, HAM., et al. 2020. mSphere. 5: PMID: 31996424
- The EcCLC antiporter embedded in lipidic liquid crystalline films - molecular dynamics simulations and electrochemical methods. | Miszta, P., et al. 2022. Phys Chem Chem Phys. 24: 3066-3077. PMID: 35040466
- Ion transport by lasalocid A across red-blood-cell membranes. A multinuclear NMR study. | Fernandez, E., et al. 1987. Eur J Biochem. 167: 353-9. PMID: 3622520
- An isoelectric focusing procedure for erythrocyte membrane proteins and its use for two-dimensional electrophoresis. | Dockham, PA., et al. 1986. Anal Biochem. 153: 102-15. PMID: 3963374
Inhibitor of:
band 3, claudin-2, Clca6, CLCC1, CLIC1, connexin 30, Eapa2, Gβ 5, Ik1, LRRC8A, LRRC8B, LRRC8C, OTOP1, OTOP2, Prestin, SNAT1, TMEM107, and VDAC3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DIDS, Disodium Salt, 25 mg | sc-203919A | 25 mg | $50.00 | |||
DIDS, Disodium Salt, 100 mg | sc-203919B | 100 mg | $160.00 | |||
DIDS, Disodium Salt, 250 mg | sc-203919 | 250 mg | $280.00 | |||
DIDS, Disodium Salt, 1 g | sc-203919C | 1 g | $670.00 |