TIP120 Activators
TIP120 Activators encompass a variety of chemical compounds that indirectly augment the functional activity of TIP120, particularly in the realm of protein degradation through the ubiquitin-proteasome system. Compounds like Forskolin, LY294002, Wortmannin, and Rapamycin operate through distinct pathways such as cAMP-PKA, PI3K/AKT, and mTOR, respectively. Forskolin, by elevating cAMP, activates PKA, influencing substrates that interact with TIP120, thus enhancing its role in ubiquitin-mediated protein degradation. LY294002 and Wortmannin, as PI3K inhibitors, alter the PI3K/AKT signaling, a pathway crucial for multiple cellular processes, including those governing protein degradation, thereby indirectly facilitating TIP120's functional role. Rapamycin, by inhibiting mTOR, also impacts protein synthesis and degradation pathways, indirectly augmenting TIP120's involvement in these processes.
Further, compounds like PD98059, U0126, SP600125, SB203580, Trichostatin A, Okadaic Acid, KN-93, and Thapsigargin provide additional layers of indirect activation mechanisms for TIP120. PD98059 and U0126, both targeting the MAPK/ERK pathway, influence TIP120 by modulating processes linked to the ubiquitin-proteasome system. SP600125 and SB203580, which inhibit JNK and p38 MAPK, respectively, also contribute to the regulation of protein degradation pathways involving TIP120. Trichostatin A, by affecting chromatin structure and gene expression, can influence cellular pathways in which TIP120 is a key player. Okadaic Acid, through its role in protein phosphorylation, and KN-93, as a CaMKII inhibitor, both indirectly modulate cellular processes that can enhance TIP120's role in protein degradation. Thapsigargin, by disrupting calcium homeostasis, influences calcium-dependent signaling pathways, thereby impacting TIP120's functional activity in the cellular protein degradation machinery. Collectively, these TIP120 Activators, through their targeted effects on various signaling pathways, facilitate the enhancement of TIP120's role in protein degradation without direct activation or upregulation.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, by increasing intracellular cAMP levels, indirectly enhances TIP120 activity. Elevated cAMP activates PKA, which can phosphorylate various substrates, including those involved in TIP120-associated ubiquitination processes, thereby influencing TIP120's role in protein degradation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K inhibitor, indirectly affects TIP120 activity by altering the PI3K/AKT pathway. This modification in signaling dynamics can influence TIP120's interaction with the ubiquitin-proteasome system, enhancing its functional role in protein degradation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059, an MEK inhibitor, indirectly enhances TIP120 function by modulating the MAPK/ERK pathway. This pathway's alteration can impact TIP120's role in the ubiquitin-proteasome system, indirectly facilitating its activity in protein degradation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125, a JNK inhibitor, influences TIP120 activity by modulating the JNK pathway. This modulation may affect TIP120's role in protein degradation through the ubiquitin-proteasome system. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, a p38 MAPK inhibitor, indirectly influences TIP120 function by altering the p38 MAPK pathway. This change can enhance TIP120's role in the ubiquitin-proteasome system for protein degradation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an mTOR inhibitor, indirectly affects TIP120 activity by modulating the mTOR pathway, which plays a role in protein synthesis and degradation. This modulation can enhance TIP120's function in the ubiquitin-proteasome system. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, another PI3K inhibitor, similarly to LY294002, affects TIP120 by altering the PI3K/AKT pathway, thus potentially enhancing TIP120's involvement in protein degradation processes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, can indirectly enhance TIP120 activity by altering chromatin structure and gene expression patterns, potentially affecting TIP120's role in the ubiquitin-proteasome pathway. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid, a protein phosphatase inhibitor, indirectly influences TIP120 by altering phosphorylation states of various proteins, potentially enhancing TIP120's involvement in protein degradation pathways. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126, an MEK1/2 inhibitor, similarly to PD98059, can indirectly enhance TIP120 activity by affecting the MAPK/ERK pathway, potentially influencing TIP120's function in protein degradation. | ||||||