TGIF Activators
TGIF (TG-interacting factor) Activators belong to a specialized category of chemical compounds designed to modulate the activity of TGIF proteins. TGIF is a family of transcriptional corepressors that play critical roles in regulating gene expression during various cellular processes, including embryonic development, tissue differentiation, and cell cycle regulation. These proteins are known to interact with other transcription factors and chromatin remodeling complexes, influencing the transcriptional activity of target genes. TGIF proteins have been associated with diverse biological pathways, making them important players in cellular physiology.
TGIF Activators are compounds engineered to interact with TGIF proteins and modify their regulatory functions. These activators can either enhance or inhibit the interactions between TGIF and its binding partners, such as other transcription factors or co-repressors, by targeting specific domains or regions within TGIF proteins. By modulating TGIF activity, these compounds have the ability to impact gene expression patterns and cellular processes governed by TGIF-regulated pathways. Research into TGIF Activators provides valuable insights into the intricate mechanisms of gene regulation and transcriptional control, shedding light on the broader roles of TGIF proteins in various biological contexts. Understanding how TGIF proteins function and how they can be modulated offers new avenues for investigating gene expression patterns and cellular responses during development and homeostasis. Researchers continue to explore the precise mechanisms of TGIF activation and its implications in diverse biological processes to unravel the complexities of transcriptional regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
A selective inhibitor of ALK5, ALK4, and ALK7, which are TGF-β type I receptors, thus indirectly affecting TGIF activity via TGF-β signaling modulation. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $105.00 $153.00 | 4 | |
A potent ATP-competitive inhibitor of TGFβR-I (ALK5), altering TGF-β signaling and thereby impacting TGIF. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $198.00 $650.00 | 16 | |
Inhibits ALK5, ALK4, and ALK7, leading to altered TGF-β signaling, indirectly influencing TGIF function. | ||||||
LY2157299 | 700874-72-2 | sc-391123 sc-391123A | 5 mg 10 mg | $209.00 $352.00 | 3 | |
A selective ATP-mimetic inhibitor of TGF-β receptor I, modifying the TGF-β/TGIF signaling pathway. | ||||||
ALK5 Inhibitor II | 446859-33-2 | sc-221234 sc-221234A sc-221234B sc-221234C sc-221234D sc-221234E sc-221234F | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $75.00 $150.00 $215.00 $650.00 $1224.00 $4296.00 $7818.00 | 8 | |
Selectively inhibits ALK5, impacting TGF-β signaling and consequently TGIF activity. | ||||||
EW-7197 | 1352608-82-2 | sc-507465 | 5 mg | $345.00 | ||
A selective ALK5 inhibitor, affecting TGF-β signaling pathways and thus indirectly TGIF function. | ||||||
TGF-β RI Kinase Inhibitor V | 627536-09-8 | sc-203294 | 2 mg | $86.00 | 3 | |
A TGF-βR1 kinase inhibitor, modulating TGF-β signaling and indirectly influencing TGIF. | ||||||
Pirfenidone | 53179-13-8 | sc-203663 sc-203663A | 10 mg 50 mg | $100.00 $408.00 | 6 | |
Although primarily known for its anti-fibrotic properties, it can modulate TGF-β signaling, thereby affecting TGIF indirectly. | ||||||
Tranilast | 53902-12-8 | sc-200389 sc-200389A sc-200389B sc-200389C | 10 mg 50 mg 1 g 5 g | $30.00 $101.00 $277.00 $959.00 | 2 | |
A compound that can modulate TGF-β activity, thus indirectly influencing TGIF. | ||||||
Smad3 Inhibitor, SIS3 | 1009104-85-1 | sc-222318 | 1 mg | $252.00 | 36 | |
A specific inhibitor of Smad3, a downstream effector in the TGF-β pathway, indirectly affecting TGIF. | ||||||