Date published: 2026-3-3

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TGFβ1 Activators

The chemical class TGFβ1 Activators hasn't been explicitly defined in the sources I accessed. However, various substances and mechanisms can activate Transforming Growth Factor Beta 1 (TGFβ1), a multifunctional cytokine involved in cell growth, differentiation, and various other cellular processes. TGFβ1 is essential for early tissue response to injury, and its activation can be mediated by molecules like αv integrins. Activation of TGFβ1 is tightly regulated; it's initially produced in a latent form that requires activation to function. The transition from latent to active TGFβ1 is a crucial regulatory step. For instance, the extracellular concentration of TGFβ activity is primarily controlled by the conversion of latent TGFβ to active TGFβ, with tissues containing significant quantities of latent TGFβ 3. Various signaling pathways and molecules can induce the activation of TGFβ1. For example, signaling pathways involving transcription factors like C/EBPβ and Sp1 modulate TGFβ1 expression and activation. Additionally, substances like thrombospondin-1 are known to play a significant role in activating TGFβ1 in vivo. Some signaling pathways involved in TGFβ1 activation include the TGFβ activated kinase 1/tumour necrosis factor receptor-associated factor 6/P38 mitogen activated protein kinase (TAK1-TRAF6-P38 MAPK) pathway and Smad4, which are essential for TGFβ1-induced autophagy. Moreover, TGFβ1 signaling is also known to interact with epidermal growth factor receptor (EGFR) activation, demonstrating the complex interplay of signaling networks in controlling TGFβ1 activity.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Retinoic acid may increase TGFβ1 expression by modulating retinoic acid receptors which in turn can influence the signaling pathways that control the expression of TGFβ1.

Cholecalciferol

67-97-0sc-205630
sc-205630A
sc-205630B
1 g
5 g
10 g
$71.00
$163.00
$296.00
2
(1)

Cholecalciferol can potentially enhance TGFβ1 expression through the Vitamin D receptor, influencing the signaling pathways that control TGFβ1 expression.

Tamoxifen

10540-29-1sc-208414
2.5 g
$272.00
18
(2)

Tamoxifen may modulate TGFβ1 expression through its actions as a selective estrogen receptor modulator which may impact the signaling pathways controlling TGFβ1 expression.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Curcumin may increase TGFβ1 expression through its anti-inflammatory properties and its ability to modulate various signaling pathways that control TGFβ1 expression.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Resveratrol may induce TGFβ1 expression through its antioxidant properties and its ability to modulate various signaling pathways that are involved in the expression of TGFβ1.

Caffeic Acid

331-39-5sc-200499
sc-200499A
1 g
5 g
$32.00
$62.00
1
(2)

Caffeic acid may promote TGFβ1 expression through its antioxidant properties and its ability to modulate signaling pathways that control TGFβ1 expression.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$45.00
$164.00
$200.00
$402.00
$575.00
$981.00
$2031.00
46
(1)

Genistein may modulate TGFβ1 expression through its actions as a phytoestrogen, which may impact the signaling pathways controlling TGFβ1 expression.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

Quercetin may enhance TGFβ1 expression through its anti-inflammatory and antioxidant properties which may influence the signaling pathways controlling TGFβ1 expression.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$153.00
$292.00
$489.00
$1325.00
$8465.00
$933.00
22
(1)

D,L-Sulforaphane may enhance TGFβ1 expression through its ability to modulate antioxidant response elements which in turn may impact the signaling pathways controlling TGFβ1 expression.

Lycopene

502-65-8sc-205738
sc-205738A
sc-205738B
1 mg
5 mg
1 g
$146.00
$582.00
$6248.00
4
(1)

Lycopene may enhance TGFβ1 expression through its antioxidant properties which may modulate the signaling pathways controlling the expression of TGFβ1.