TFIIH p44 Activators
The TFIIH p44 activators belong to a specific chemical class intricately involved in the regulation of transcription, a fundamental process that governs the synthesis of RNA from DNA. Transcription factor IIH (TFIIH) is a multi-subunit protein complex crucial for the initiation of transcription by RNA polymerase II. Among its subunits, the p44 subunit plays a pivotal role in facilitating the unwinding of DNA during transcription initiation. The TFIIH p44 activators represent a set of compounds or molecules that modulate the activity of the p44 subunit, influencing the overall efficiency and accuracy of the transcription process.
In terms of molecular mechanism, TFIIH p44 activators are thought to interact with the p44 subunit, inducing conformational changes that enhance its ability to unwind DNA strands. This activation of p44 is crucial for the formation of the transcription initiation complex, allowing RNA polymerase II to access the DNA template and commence the synthesis of RNA. The regulation of transcription initiation is a finely tuned process, and the modulation of TFIIH p44 activity by these activators underscores their significance in the intricate molecular machinery governing gene expression. Understanding the structural and functional aspects of TFIIH p44 activators is essential for unraveling the complexities of transcriptional regulation, providing valuable insights into the molecular mechanisms that underlie gene expression in various cellular contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. It can enhance TFIIH p44 function by inhibiting the PI3K/AKT pathway, which otherwise would decrease TFIIH's activity in DNA repair. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates the SIRT1 pathway, which in turn enhances the interaction between TFIIH p44 and other components of the TFIIH complex, thus increasing its activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to interact with the NF-κB pathway. By inhibiting this pathway, it can enhance TFIIH p44's activity in DNA repair mechanisms. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin can enhance TFIIH p44's function by inhibiting the JAK/STAT signaling pathway, which negatively modulates TFIIH's activity. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol can inhibit the MAPK pathway, which in turn enhances TFIIH p44's activity in DNA repair mechanisms. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can inhibit the mTOR pathway, which otherwise would decrease TFIIH's activity, hence enhancing TFIIH p44's function. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, which in turn increases the activity of TFIIH p44 in DNA repair mechanisms. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin, by inhibiting the NF-κB pathway, can enhance TFIIH p44's activity in DNA repair mechanisms. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin can inhibit the PI3K/AKT pathway, which negatively modulates TFIIH's activity, thus enhancing TFIIH p44's function. | ||||||
Fisetin | 528-48-3 | sc-276440 sc-276440A sc-276440B sc-276440C sc-276440D | 50 mg 100 mg 500 mg 1 g 100 g | $52.00 $79.00 $104.00 $156.00 $2913.00 | 7 | |
Fisetin can activate the SIRT1 pathway, which enhances the interaction between TFIIH p44 and other components of the TFIIH complex, thus increasing its activity. | ||||||