TFIIH p44 Antibody (GTF2F6A10): sc-81402

TFIIH p44 Antibody (GTF2F6A10) is a mouse monoclonal IgG1 antibody that detects TFIIH p44 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-TFIIH p44 antibody (GTF2F6A10) is available as a non-conjugated format. TFIIH p44 plays a crucial role in transcription and DNA repair mechanisms, functioning as part of the larger TFIIH complex, which is essential for DNA unwinding during transcription and nucleotide excision repair. TFIIH p44 is located in the nucleus, where TFIIH p44 interacts with other transcription factors and DNA repair proteins, facilitating RNA polymerase II recruitment to gene promoter regions. Proper functioning of TFIIH p44 is vital, as defects can lead to transcriptional dysregulation and increased susceptibility to DNA damage, which are implicated in various diseases, including cancer. TFIIH complex, which includes additional subunits such as p89 and p80, exhibits ATP-dependent helicase activity, underscoring TFIIH p44′s importance in maintaining genomic stability and regulating gene expression.

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TFIIH p44 Antibody (GTF2F6A10) References:

1. Factors involved in specific transcription by mammalian RNA polymerase II. Identification and characterization of factor IIH.  |  Flores, O., et al. 1992. J Biol Chem. 267: 2786-93. PMID: 1733973
2. Purification and interaction properties of the human RNA polymerase B(II) general transcription factor BTF2.  |  Gerard, M., et al. 1991. J Biol Chem. 266: 20940-5. PMID: 1939143
3. A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne's syndrome.  |  Weeda, G., et al. 1990. Cell. 62: 777-91. PMID: 2167179
4. ERCC2: cDNA cloning and molecular characterization of a human nucleotide excision repair gene with high homology to yeast RAD3.  |  Weber, CA., et al. 1990. EMBO J. 9: 1437-47. PMID: 2184031
5. An RNA polymerase II transcription factor has an associated DNA-dependent ATPase (dATPase) activity strongly stimulated by the TATA region of promoters.  |  Conaway, RC. and Conaway, JW. 1989. Proc Natl Acad Sci U S A. 86: 7356-60. PMID: 2552440
6. p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair.  |  Humbert, S., et al. 1994. EMBO J. 13: 2393-8. PMID: 8194529
7. Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH.  |  Marinoni, JC., et al. 1997. EMBO J. 16: 1093-102. PMID: 9118947
8. Cloning of the 62-kilodalton component of basic transcription factor BTF2.  |  Fischer, L., et al. 1992. Science. 257: 1392-5. PMID: 1529339

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TFIIH p44 Antibody (GTF2F6A10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TFIIH p44 Antibody (GTF2F6A10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TFIIH p44 Antibody (GTF2F6A10) Specifications

Alternate Product Name: TFIIH p44

Product Clone Name: GTF2F6A10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: TFIIH p44

Epitope Species: human

Product Reactivity/Detection: TFIIH p44

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TFIIH p44 Antibody (GTF2F6A10): N/A