TERT Inhibitors
Items 1 to 10 of 15 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Doxorubicin hydrochloride | 25316-40-9 | sc-200923 sc-200923B sc-200923A sc-200923C sc-200923D | 5 mg 10 mg 25 mg 100 mg 250 mg | $85.00 $150.00 $210.00 $290.00 $520.00 | 31 | |
Doxorubicin hydrochloride exhibits unique interactions as a terminal deoxynucleotidyl transferase (TERT) substrate, characterized by its planar aromatic structure that facilitates intercalation between DNA bases. This intercalation alters the DNA conformation, enhancing the enzyme's binding affinity. The compound's electrostatic properties and hydrophilic regions promote effective enzyme-substrate interactions, influencing reaction kinetics and stability during nucleotide incorporation. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Suramin sodium acts as a terminal deoxynucleotidyl transferase (TERT) substrate, showcasing distinctive binding dynamics due to its multi-functional sulfonate groups. These groups enhance solubility and facilitate specific electrostatic interactions with the enzyme, promoting a stable enzyme-substrate complex. The compound's rigid structure influences the conformational flexibility of TERT, thereby modulating the kinetics of nucleotide addition and enhancing the overall efficiency of the enzymatic process. | ||||||
BIBR 1532 | 321674-73-1 | sc-203843 sc-203843A | 10 mg 50 mg | $189.00 $733.00 | 6 | |
BIBR 1532 is a potent and specific inhibitor of telomerase enzymatic activity. It directly binds to TERT, leading to telomere shortening. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A functions as a TERT modulator, exhibiting unique interactions through its hydroxamic acid moiety, which chelates zinc ions in the enzyme's active site. This interaction alters the enzyme's conformation, enhancing its affinity for telomeric DNA. The compound's ability to disrupt histone deacetylation pathways further influences chromatin structure, impacting gene expression and cellular aging processes. Its dynamic binding kinetics contribute to the regulation of telomere maintenance. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a major component of green tea, has been shown to inhibit TERT expression, potentially through modulation of the NF-kB pathway. | ||||||
Telomerase Inhibitor IX | 368449-04-1 | sc-204333 | 10 mg | $200.00 | 2 | |
MST-312 is a potent telomerase inhibitor. It acts directly on the enzyme, leading to telomere shortening over time. | ||||||
beta-Rubromycin | 27267-70-5 | sc-204636 sc-204636A | 1 mg 5 mg | $177.00 $712.00 | ||
β-Rubromycin acts as a TERT modulator, characterized by its ability to form stable complexes with metal ions, which can influence enzyme activity. Its unique structural features allow for selective binding to specific protein domains, potentially altering conformational dynamics. The compound's reactivity as an acid halide facilitates nucleophilic attack, leading to distinct reaction pathways that can modulate telomerase activity. This interplay of interactions may impact cellular processes related to telomere dynamics. | ||||||
BPPA | sc-200885 | 5 mg | $57.00 | 1 | ||
BPPA functions as a TERT modulator, exhibiting a distinctive ability to engage in hydrogen bonding and π-π stacking interactions with nucleic acid structures. Its unique electronic properties enhance its reactivity, allowing for selective modification of target sites within biomolecules. The compound's role as an acid halide promotes rapid acylation reactions, influencing the kinetics of telomerase assembly and activity. This multifaceted behavior underscores its potential to impact telomere maintenance mechanisms. | ||||||
TMPyP4 | 36951-72-1 | sc-204346 sc-204346A sc-204346B | 25 mg 250 mg 500 mg | $108.00 $159.00 $287.00 | 9 | |
TMPyP4 is a cationic porphyrin that can inhibit telomerase activity, potentially by disrupting the structure of telomeric G-quadruplexes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been found to suppress TERT expression, possibly through the inhibition of the Akt pathway. | ||||||