Molecular structure of BIBR 1532, CAS Number: 321674-73-1
BIBR 1532 (CAS 321674-73-1)
See product citations (6)
Alternate Names:
(E)-2-(3-(naphthalen-2-yl)but-2-enamido)benzoic acid
Application:
BIBR 1532 is a selective telomerase inhibitor
CAS Number:
321674-73-1
Purity:
≥96%
Molecular Weight:
331.37
Molecular Formula:
C21H17NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BIBR 1532 is a compound suggested to act as a selective and specific TERT (telomerase) inhibitor. Studies indicate that BIBR 1532 inhibits the TERT (reverse transcriptase of telomerase, hTERT), and shortens the length of the telomere. In addition, reports indicate that BIBR 1532 has the ability to stop cell proliferation in lung cancer cell studies after 120 days.
BIBR 1532 (CAS 321674-73-1) References
- A highly selective telomerase inhibitor limiting human cancer cell proliferation. | Damm, K., et al. 2001. EMBO J. 20: 6958-68. PMID: 11742973
- Inhibition of telomerase by BIBR 1532 and related analogues. | Barma, DK., et al. 2003. Bioorg Med Chem Lett. 13: 1333-6. PMID: 12657276
- Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532. | El-Daly, H., et al. 2005. Blood. 105: 1742-9. PMID: 15507522
- Pharmacological telomerase inhibition can sensitize drug-resistant and drug-sensitive cells to chemotherapeutic treatment. | Ward, RJ. and Autexier, C. 2005. Mol Pharmacol. 68: 779-86. PMID: 15939802
- Telomerase and its potential for therapeutic intervention. | Phatak, P. and Burger, AM. 2007. Br J Pharmacol. 152: 1003-11. PMID: 17603541
- Telomerase inhibitors and 'T-oligo' as cancer therapeutics: contrasting molecular mechanisms of cytotoxicity. | Rankin, AM., et al. 2008. Anticancer Drugs. 19: 329-38. PMID: 18454043
- Consequences of telomerase inhibition by BIBR1532 on proliferation and chemosensitivity of chondrosarcoma cell lines. | Parsch, D., et al. 2008. Cancer Invest. 26: 590-6. PMID: 18584350
- Direct short-term cytotoxic effects of BIBR 1532 on acute promyelocytic leukemia cells through induction of p21 coupled with downregulation of c-Myc and hTERT transcription. | Bashash, D., et al. 2012. Cancer Invest. 30: 57-64. PMID: 22236190
- BIBR 1532 increases arsenic trioxide-mediated apoptosis in acute promyelocytic leukemia cells: therapeutic potential for APL. | Bashash, D., et al. 2013. Anticancer Agents Med Chem. 13: 1115-25. PMID: 23293885
- Glucose restriction decreases telomerase activity and enhances its inhibitor response on breast cancer cells: possible extra-telomerase role of BIBR 1532. | Wardi, L., et al. 2014. Cancer Cell Int. 14: 60. PMID: 25089119
- Telomerase inhibition decreases alpha-fetoprotein expression and secretion by hepatocellular carcinoma cell lines: in vitro and in vivo study. | Tahtouh, R., et al. 2015. PLoS One. 10: e0119512. PMID: 25822740
- Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation. | Beyer, AM., et al. 2016. Circ Res. 118: 856-66. PMID: 26699654
- Inhibition of telomerase potentiates enzalutamide efficiency of androgen-sensitive human prostate cancer cells. | Gecgel, KK., et al. 2017. J BUON. 22: 1570-1576. PMID: 29332354
Inhibitor of:
CCXCKR, CKR-6, Est1, NG2, PINX1, RTEL1, Shelterin complex, Tel1, TEN1, TERC, TERT, TP1, TRF1, TRF2, and TRT.Activator of:
Pot1b, and TRT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BIBR 1532, 10 mg | sc-203843 | 10 mg | $189.00 | |||
BIBR 1532, 50 mg | sc-203843A | 50 mg | $733.00 |